Association between the risk and severity of Parkinson's disease and plasma homocysteine, vitamin B12 and folate levels: a systematic review and meta-analysis

Y Quan, J Xu, Q Xu, Z Guo, R Ou, H Shang… - Frontiers in Aging …, 2023 - frontiersin.org
Background Parkinson's disease (PD) is recognized as the second most prevalent
progressive neurodegenerative disease among the elderly. However, the relationship …

Methionine Restriction Diets: Unravelling Biological Mechanisms and Enhancing Brain Health

Y Liu, J Guo, H Cheng, J Wang, Y Tan, J Zhang… - Trends in Food Science …, 2024 - Elsevier
Abstract Background Methionine (Met) uptake and metabolism are integral to various
cellular functions. Excessive intake of Met from human diets can lead to numerous health …

Inhibition of abnormal C/EBPβ/α‐Syn signaling pathway through activation of Nrf2 ameliorates Parkinson's disease‐like pathology

Z Lin, L Huang, Q Cao, H Luo, W Yao, J Zhang - Aging Cell, 2023 - Wiley Online Library
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain.
These LBs are primarily composed of α‐Synuclein (α‐Syn), which has aggregated. A recent …

N‐homocysteinylation of DJ‐1 promotes neurodegeneration in Parkinson's disease

T Guo, L Zhou, M Xiong, J Xiong, J Huang, Y Li… - Aging …, 2024 - Wiley Online Library
DJ‐1, also known as Parkinson's disease protein 7 (Park7), is a multifunctional protein that
regulates oxidative stress and mitochondrial function. Dysfunction of DJ‐1 is implicated in …

Depletion of bleomycin hydrolase (Blmh) downregulates histone demethylase Phf8, impairs mTOR signaling/autophagy, accelerates amyloid beta accumulation, and …

Ł Witucki, K Borowczyk, J Suszyńska-Zajczyk… - bioRxiv, 2023 - biorxiv.org
Bleomycin hydrolase (BLMH), a homocysteine (Hcy)-thiolactone detoxifying enzyme, is
attenuated in brains of Alzheimer's disease patients. In mice, Blmh depletion causes …

Deletion of the homocysteine thiolactone detoxifying enzyme bleomycin hydrolase, in mice, causes memory and neurological deficits and worsens alzheimer's …

Ł Witucki, K Borowczyk… - Journal of …, 2023 - content.iospress.com
Background: Bleomycin hydrolase (BLMH), a homocysteine (Hcy)-thiolactone detoxifying
enzyme, is attenuated in Alzheimer's disease (AD) brains. Blmh loss causes astrogliosis in …

Caffeine weakens the astringency of epigallocatechin gallate by inhibiting its interaction with salivary proteins

Z Zhou, M Ou, W Shen, W Jin, G Yang, W Huang… - Food Chemistry, 2024 - Elsevier
The astringency of green tea is an integrated result of the synergic and antagonistic effects
of individual tea components, whose mechanism is highly complex and not completely …

[HTML][HTML] The Imbalance of Homocysteine, Vitamin B12 and Folic Acid in Parkinson Plus Syndromes: A Review beyond Parkinson Disease

V Poulidou, I Liampas, M Arnaoutoglou, E Dardiotis… - Biomolecules, 2024 - mdpi.com
While there is a link between homocysteine (Hcy), B12 and folic acid and
neurodegeneration, especially in disorders like Parkinson's and Alzheimer's diseases, its …

[HTML][HTML] α-Synuclein pathology from the body to the brain: so many seeds so close to the central soil

Y Yang, Z Zhang - Neural Regeneration Research, 2024 - journals.lww.com
Abstract α-Synuclein is a protein that mainly exists in the presynaptic terminals. Abnormal
folding and accumulation of α-synuclein are found in several neurodegenerative diseases …

Association of Plasma Homocysteine with Cognitive Impairment in Patients with Parkinson's Disease

Y Xiao, LH Gan, X Liang, Z Xu, TY Hu, XY Li… - Frontiers in Aging …, 2024 - frontiersin.org
Background: Elevated plasma homocysteine (Hcy) has been reported as a risk factor for
cognitive impairment in the general population. However, there are conflicting results …