Background Gait impairment contributes to falls and frailty. Some studies suggest that
cerebral small vessel disease (CSVD) is associated with gait impairment in the general …

Background Elevated blood pressure (BP) has been linked to impaired cognition and
dementia in older adults. However, few studies have accounted for long-term cumulative BP …

Recent reports suggest declines in the age-specific risk of Alzheimer's dementia in higher
income Western countries. At the same time, investigators believe that worldwide trends of …

Disease heterogeneity has been a critical challenge for precision diagnosis and treatment,
especially in neurologic and neuropsychiatric diseases. Many diseases can display multiple …

Little is known about whether the association of hypertension with brain volume and
dementia is modified by an individual's age at their diagnosis of hypertension. Our analysis …

Hypertension is one of the most prevalent vascular risk factors and a leading cause of
disability and mortality worldwide. The negative impact of hypertension on brain health is …

Aims Elevated blood pressure (BP) is a prevalent modifiable risk factor for cardiovascular
diseases and contributes to cognitive decline in late life. Despite the fact that functional …

Background: Mid-life hypertension is an established risk factor for cognitive impairment and
dementia and related to greater brain atrophy and poorer cognitive performance. Previous …

Background Serum uric acid (SUA) has been demonstrated as a risk factor for myocardial
infarction (MI) and all‐cause mortality; however, the impact of cumulative SUA (cumSUA) …

Background The impact of long-term serum uric acid (SUA) exposure and time course of
SUA accumulation on diabetes mellitus (DM) is unknown. This study aimed to evaluate the …