Background The liver is a key regulator of systemic energy homeostasis and can sense and
respond to nutrient excess and deficiency through crosstalk with multiple tissues. Regulation …

With the understanding of the complex interaction between the tumour microenvironment
and immunotherapy, there is increasing interest in the role of immune regulators in the …

Summary Lymphocyte-activation gene 3 (LAG-3) is an immune inhibitory receptor, with
major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains …

Immune checkpoint therapy has achieved significant efficacy by blocking inhibitory
pathways to release the function of T lymphocytes. In the clinic, anti-programmed cell death …

The incidence of hepatocellular carcinoma (HCC) is increasing in industrialized societies;
this is likely secondary to the increasing burden of non-alcoholic fatty liver disease (NAFLD) …

Liver disease is the spectrum of liver damage ranging from simple steatosis called as
nonalcoholic fatty liver disease (NAFLD) to hepatocellular carcinoma (HCC). Clinically …

Novel therapeutic approaches combining immune-checkpoint inhibitors are needed to
improve clinical outcomes for patients with cancer. Lymphocyte-activation gene 3 (LAG-3) is …

Fibrinogen-associated protein (FREP) family is a family of proteins with a fibrin domain at the
carboxyl terminus. Recent investigations illustrated that two members of FREP family …

Background & Aims The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor
regulating bile acid, glucose and cholesterol homeostasis. Obeticholic acid (OCA), a …

Aims/hypothesis Type 2 diabetes is highly correlated with nonalcoholic fatty liver disease
(NAFLD). Hepatocyte-derived fibrinogen-related protein 1 (HFREP1) is a hepatokine that …