Sepsis-induced myocardial dysfunction

KR Walley - Current opinion in critical care, 2018 - journals.lww.com
Sepsis-induced myocardial dysfunction is increasingly recognized as a major contributor to
outcome of septic shock. Significant strides have been made in understanding the …

The renin–angiotensin–aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

M Legrand, AK Khanna, M Ostermann, Y Kotani… - Critical Care, 2024 - Springer
Dysregulation of the renin–angiotensin–aldosterone-system (RAAS) in sepsis is a complex
and early phenomenon with a likely significant contribution to organ failure and patient …

[HTML][HTML] Matairesinol exerts anti-inflammatory and antioxidant effects in sepsis-mediated brain injury by repressing the MAPK and NF-κB pathways through up …

Q Wu, Y Wang, Q Li - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Brain injury is a familiar complication of severe sepsis, in which excessive inflammation and
oxidative stress are the main mechanisms leading to acute brain injury. Here, we focus on …

Acetyl‐11‐Keto‐β‐Boswellic Acid (AKBA) Prevents Lipopolysaccharide‐Induced Inflammation and Cytotoxicity on H9C2 Cells

D Taherzadeh, V Baradaran Rahimi… - Evidence‐Based …, 2022 - Wiley Online Library
Acetyl‐11‐keto‐beta‐boswellic acid (AKBA), the major component of Boswellia serrata,
exhibits anti‐inflammatory activities. This in vitro study investigated the protective effects of …

Long non-coding RNA GAS5 aggravates myocardial depression in mice with sepsis via the microRNA-449b/HMGB1 axis and the NF-κB signaling pathway

H Gao, H Ma, M Gao, A Chen, S Zha… - Bioscience Reports, 2021 - portlandpress.com
Sepsis is a common cause of deaths of patients in intensive care unit. The study aims to
figure out the role of long non-coding RNA (lncRNA) GAS5 in the myocardial depression in …

[HTML][HTML] Small interfering RNA-induced silencing lncRNA PVT1 inhibits atherosclerosis via inactivating the MAPK/NF-κB pathway

H Du, H Zhang, R Yang, L Qiao, H Shao… - Aging (Albany NY …, 2021 - ncbi.nlm.nih.gov
Atherosclerosis (AS) is a chronic disease of the arterial wall. The role of lncRNAs in AS has
been acknowledged. This study investigated the role of lncRNA plasmacytoma variant …

Therapeutic approaches targeting renin-angiotensin system in sepsis and its complications

L Ning, J Rong, Z Zhang, Y Xu - Pharmacological Research, 2021 - Elsevier
Sepsis, caused by the inappropriate host response to infection, is characterized by
excessive inflammatory response and organ dysfunction, thus becomes a critical clinical …

Irbesartan has a curative effect on lipopolysaccharide-induced cardiotoxicity by antioxidant and antiapoptotic pathways

MY Tepebaşi, H Aşci, S Coşan, MA Sevük… - Revista Portuguesa de …, 2023 - Elsevier
Abstract Introduction and Objective Lipopolysaccharide (LPS) has been associated with
myocardial inflammation, oxidative stress, apoptosis, and cardiac dysfunction, as well as …

Protective effect of ertugliflozin against acute lung injury caused by endotoxemia model in mice

AQ Abd Uljaleel, ES Hassan - Iranian Journal of War and Public Health, 2023 - ijwph.ir
Aims: Endotoxemic shock is characterized by multiple organ dysfunction, acute Lung Injury,
acute respiratory distress syndrome, and high mortality. This study aimed to investigate the …

Neuroprotective effect of semaglutide in endotoxemia mouse model

AA Shnaien, AR Mohammad, ES Hassan - … Journal of War and Public Health, 2023 - ijwph.ir
Aims: This study was done to investigate the potential neuroprotective effect of semaglutide
during endotoxemia in mice. Material and method: 24 adult male Swiss-albino mice aged 8 …