Targeting biomolecular condensation and protein aggregation against cancer

JL Silva, D Foguel, VF Ferreira, TCRG Vieira… - Chemical …, 2023 - ACS Publications
Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Traditional Chinese medicine as a cancer treatment: Modern perspectives of ancient but advanced science

Y Xiang, Z Guo, P Zhu, J Chen, Y Huang - Cancer medicine, 2019 - Wiley Online Library
Traditional Chinese medicine (TCM) has been practiced for thousands of years and at the
present time is widely accepted as an alternative treatment for cancer. In this review, we …

[HTML][HTML] Progress to improve oral bioavailability and beneficial effects of resveratrol

A Chimento, F De Amicis, R Sirianni… - International journal of …, 2019 - mdpi.com
Resveratrol (3, 5, 4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present
in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro …

Piceatannol: A natural stilbene for the prevention and treatment of cancer

K Banik, AM Ranaware, C Harsha, T Nitesh… - Pharmacological …, 2020 - Elsevier
Abstract The World Health Organization (WHO) has documented that cancer is the second
foremost reason for death worldwide. Various factors are responsible for cancer, for …

Resveratrol in breast cancer treatment: from cellular effects to molecular mechanisms of action

M Behroozaghdam, M Dehghani, A Zabolian… - Cellular and Molecular …, 2022 - Springer
Breast cancer (BC) is one of the most common cancers in females and is responsible for the
highest cancer-related deaths following lung cancer. The complex tumor microenvironment …

Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands

EC Petronilho, MM Pedrote, MA Marques… - Chemical …, 2021 - pubs.rsc.org
Mutant p53 tends to form aggregates with amyloid properties, especially amyloid oligomers
inside the nucleus, which are believed to cause oncogenic gain-of-function (GoF). The …

Inhibition of p53 protein aggregation as a cancer treatment strategy

K Kwan, O Castro-Sandoval, C Gaiddon… - Current Opinion in …, 2023 - Elsevier
The p53 protein plays a critical role in the prevention of genome mutations in the body,
however, this protein is frequently mutated in cancer and almost all cancers exhibit …

Influence of the bioactive diet components on the gene expression regulation

J Mierziak, K Kostyn, A Boba, M Czemplik, A Kulma… - Nutrients, 2021 - mdpi.com
Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food
constituents, which can transfer information from the external environment and influence …

Nutraceuticals in the Mediterranean diet: potential avenues for breast cancer treatment

G Augimeri, FI Montalto, C Giordano, I Barone… - Nutrients, 2021 - mdpi.com
The traditional Mediterranean Diet constitutes a food model that refers to the dietary patterns
of the population living in countries bordering the Mediterranean Sea in the early 1960s. A …

A balancing act: using small molecules for therapeutic intervention of the p53 pathway in cancer

JJ Miller, C Gaiddon, T Storr - Chemical Society Reviews, 2020 - pubs.rsc.org
Referred to as the “guardian of the genome”, p53 is the most frequently mutated protein in
cancer and almost all cancers exhibit malfunction along the p53 pathway. As an …