Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease

B Zingales, DC Bartholomeu - Memórias do instituto oswaldo cruz, 2022 - SciELO Brasil
Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …

Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection

MS Cardoso, JL Reis-Cunha… - Frontiers in …, 2016 - frontiersin.org
Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Genome-wide chromatin interaction map for Trypanosoma cruzi

F Díaz-Viraqué, ML Chiribao, MG Libisch… - Nature Microbiology, 2023 - nature.com
Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which
causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease …

Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications

A Herreros-Cabello, F Callejas-Hernández, N Gironès… - Genes, 2020 - mdpi.com
Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

A Review on the Immunological Response against Trypanosoma cruzi

G Macaluso, F Grippi, S Di Bella, V Blanda, F Gucciardi… - Pathogens, 2023 - mdpi.com
Chagas disease is a chronic systemic infection transmitted by Trypanosoma cruzi. Its life
cycle consists of different stages in vector insects and host mammals. Trypanosoma cruzi …

The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas

AD Ricci, L Bracco, E Salas-Sarduy… - Nature …, 2023 - nature.com
During an infection the immune system produces pathogen-specific antibodies. These
antibody repertoires become specific to the history of infections and represent a rich source …

A prophylactic α-Gal-based glycovaccine effectively protects against murine acute Chagas disease

S Portillo, BG Zepeda, E Iniguez, JJ Olivas, NH Karimi… - npj Vaccines, 2019 - nature.com
Chagas disease (ChD), caused by the hemoflagellate parasite Trypanosoma cruzi, affects
six to seven million people in Latin America. Lately, it has become an emerging public …

Towards high-throughput immunomics for infectious diseases: use of next-generation peptide microarrays for rapid discovery and mapping of antigenic determinants

SJ Carmona, M Nielsen, C Schafer-Nielsen… - Molecular & Cellular …, 2015 - ASBMB
Complete characterization of antibody specificities associated to natural infections is
expected to provide a rich source of serologic biomarkers with potential applications in …

Comparative analysis of virulence mechanisms of trypanosomatids pathogenic to humans

AL de Castro Neto, JF Da Silveira… - Frontiers in Cellular and …, 2021 - frontiersin.org
Trypanosoma brucei, Leishmania spp., and T. cruzi are flagellate protozoans of the family
Trypanosomatidae and the causative agents of human African trypanosomiasis …

Gene and chromosomal copy number variations as an adaptive mechanism towards a parasitic lifestyle in trypanosomatids

JL Reis-Cunha, HO Valdivia… - Current …, 2018 - ingentaconnect.com
Trypanosomatids are a group of kinetoplastid parasites including some of great public
health importance, causing debilitating and life-long lasting diseases that affect more than …