Hypercholesterolemia is an important risk factor for cardiovascular disease. It is caused by a
disturbed balance between cholesterol secretion into the blood versus uptake. The …

Hypercholesterolemia is a major risk factor for cardiovascular disease. Cholesterol
homeostasis in the body is governed by the interplay between absorption, synthesis, and …

The purpose of this review is to outline the emerging role of dietary phytosterols in human
health. Dietary saturated fat, cholesterol and fiber are currently emphasized in the reduction …

The purpose of this review is to update the reader on our current understanding of the
uptake and secretion of dietary lipid by the enterocyte to the periphery. This is a multi-stage …

Objective The objective was to determine the mechanisms of action of berberine (BBR) on
cholesterol homeostasis using in vivo and in vitro models. Methods Male Sprague–Dawley …

Using an in vitro digestion model, we studied the effect of six saponin extracts on the
bioaccessibility of cholesterol and saturated fatty acids (SFAs). In the absence of saponins …

Background The alarming rise in the obesity epidemic and growing concern for the
pathologic consequences of the metabolic syndrome warrant great need for development of …

Elevation of circulating levels of blood cholesterol, especially LDL cholesterol, and/or the
decrease of HDL cholesterol levels have long been recognized as primary risk factors for …

Humans cannot synthesize fat-soluble vitamins such as vitamin E and vitamin K. For this
reason, they must be obtained from the diet via intestinal absorption. As the deficiency or …

Previous in vivo studies including those with knockout mice suggested that Niemann-Pick
C1-like 1 (NPC1L1) plays an essential role in the intestinal absorption of cholesterol. To …