Antibiotic resistance is a major global health challenge and, worryingly, several key Gram
negative pathogens can become resistant to most currently available antibiotics. Polymyxins …

Despite efforts to develop new antibiotics, antibacterial resistance still develops too fast for
drug discovery to keep pace. Often, resistance against a new drug develops even before it …

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Background: Microbial drug resistance is one of the biggest public health problems.
Antibiotic consumption is an essential factor for the emergence and spread of multiresistant …

Covering: 1947-early 2017, particularly from 2005-early 2017 The rise of bacterial
pathogens with acquired resistance to almost all available antibiotics is becoming a serious …

Abstract Treatment of polymicrobial infections requires combination therapy with drugs that
have different antimicrobial spectra and possibly work in synergy. However, the different …

There is a need to discover and develop non-toxic antibiotics that are effective against
metabolically dormant bacteria, which underlie chronic infections and promote antibiotic …

The adoption of a new technology into basic research, and industrial and clinical settings
requires rigorous testing to build confidence in the reproducibility, reliability, robustness, and …

Drug-induced nephrotoxicity is responsible for 20% to 60% of cases of acute kidney injury in
hospitalized patients and is associated with increased morbidity and mortality in both …

Drug-induced kidney injury, largely caused by proximal tubular intoxicants, limits
development and clinical use of new and approved drugs. Assessing preclinical …