Microglia are the resident macrophages of the central nervous system. They play key roles
in brain development, and physiology during life and aging. Equipped with a variety of …

Astrocytes are highly specialized glial cells responsible for trophic and metabolic support of
neurons. They are associated to ionic homeostasis, the regulation of cerebral blood flow and …

The mechanistic basis of gliogenesis, which occurs late in human development, is poorly
understood. Here we identify nuclear factor IA (NFIA) as a molecular switch inducing human …

Neurodegenerative diseases and depression are multifactorial disorders with a complex
and poorly understood physiopathology. Astrocytes play a key role in the functioning of …

Recent studies highlighted the importance of astrocytes in neuroinflammatory diseases,
interacting closely with other CNS cells but also with the immune system. However, due to …

Neurological disorders are the leading cause of disability and the second largest cause of
death worldwide. Despite significant research efforts, neurology remains one of the most …

From the beginning, induced pluripotent stem cell (iPSC) technology was touted as a path to
improve our understanding of disease biology and enable drug discovery. Advances in …

Astrocyte dysfunction and neuroinflammation are detrimental features in multiple
pathologies of the CNS. Therefore, the development of methods that produce functional …

Mutations in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis
(ALS). Accumulating evidence implicates astrocytes as important non‐cell autonomous …

Currently, the identification of chemicals that have the potential to induce developmental
neurotoxicity (DNT) is based on animal testing. Since at the regulatory level, systematic …