Leukotrienes (LT) are a class of inflammatory mediators produced by the 5-lipoxygenase (5-
LO) enzyme from arachidonic acid (AA). We discussed the various LT inhibitors and …

Abstract Background Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are pro-inflammatory
mediators of the 5-lipooxygenase (5-LO) pathway, that play an important role in …

Because there is no curative treatment for spinal cord injury, establishing an ideal animal
model is important to identify injury mechanisms and develop therapies for individuals …

Background Inflammatory reaction in blood–spinal cord barrier (BSCB) plays a crucial role
in ischemia/reperfusion (I/R) injury. It has been shown that microglia could be activated …

Resveratrol, a polyphenol found in various plants, including grapes, plums and peanuts has
shown various medIRInal properties, including antioxidant, protection of cardiovascular …

Acute arterial occlusions via different vascular pathologies are the main causes of spinal
cord ischemia. We investigated neuroprotective effects of syringic acid on spinal cord …

Spinal cord ischemia-reperfusion injury (SCII) remains an unresolved complication and its
underlying mechanism has not been fully elucidated. In this study, we studied the role of …

Aim: The purpose of this study was to evaluate the possible protective/therapeutic effects of
aloe vera (AV) on ischemia–reperfusion injury (I/R) of spinal cord in rats. Materials and …

Several drugs are effective in attenuating intestinal ischemia-reperfusion injury (IRI);
however little is known about the effect of montelukast. Fifty rats were randomly assigned to …

Previous studies have demonstrated that pterostilbene (Pter) prevents oxidative stress,
suppresses cell growth and exhibits anti‑fungal and anti‑inflammatory effects. Pter is used to …