Abstract Introduction The protein Klotho (KL) was first discovered in KL-deficient mice, which
developed a syndrome similar to premature aging in humans. Since then, KL has been …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease; it is the most
common cause of senile dementia. Klotho, a single-pass transmembrane protein primarily …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

The organelle of eukaryotes is a finely regulated system. Once disturbed, it activates the
specific autoregulatory systems, namely, organelle autoregulation. Among which, the Golgi …

This study investigated the protective effects of melatonin (MT) against cisplatin (CP)-
induced acute kidney injury in rats as well as its possible mechanism of action associated …

The hypothalamus–pituitary–ovary axis is the most important system for regulating female
reproductive endocrine function. Its dysfunction would lead to the abnormal secretion of …

Background This study investigated the protective effects of L. reuteri ZJ617 on intestinal
and liver injury and the underlying mechanisms in modulating inflammatory, autophagy, and …

The treatment of depression with pharmaceuticals is associated with many adverse side
effects, including male fertility problems. The precise mechanisms by which these agents …

Immunosenescence in monocytes has been shown to be associated with several
biochemical and functional changes, including development of senescence-associated …

Endoplasmic reticulum stress (ER stress) just like a double-edged sword depending on
different conditions in the development of multiple hepatic diseases. But the molecular …