Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches

SE Humphries, L Morgan - The Lancet Neurology, 2004 - thelancet.com
Ischaemic stroke is the most common form of stroke and is caused by athero-sclerosis in
most patients. Several genetic determinants contribute to stroke risk. Of these, carotid intimal …

Genetic polymorphism in angiotensinogen and its association with cardiometabolic diseases

M Shahid, K Rehman, MSH Akash, S Suhail, S Kamal… - Metabolites, 2022 - mdpi.com
Angiotensinogen (AGT) is one of the most significant enzymes of the renin-angiotensin-
aldosterone system (RAAS) which is involved in the regulation and maintenance of blood …

Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis

AA Sethi, BG Nordestgaard… - … , and vascular biology, 2003 - Am Heart Assoc
Objective—The aim of this study was to investigate whether the M235T polymorphism in the
angiotensinogen gene was associated with angiotensinogen levels, systolic and diastolic …

[HTML][HTML] Molecular and pathophysiological features of angiotensinogen: a mini review

C Wu, H Lu, LA Cassis, A Daugherty - North American journal of …, 2011 - ncbi.nlm.nih.gov
The renin-angiotensin system is an essential regulatory system for blood pressure and fluid
homeostasis. Angiotensinogen is the only known precursor of all the peptides generated in …

[HTML][HTML] Genetic evaluation for coronary artery disease

MT Scheuner - Genetics in medicine, 2003 - Elsevier
There is substantial evidence that genetic factors contribute to coronary artery disease
(CAD). Currently, family history collection and interpretation is the best method for identifying …

SNPs in MicroRNA Binding Sites in 3′-UTRs of RAAS Genes Influence Arterial Blood Pressure and Risk of Myocardial Infarction

AY Nossent, JL Hansen, C Doggen… - American journal of …, 2011 - academic.oup.com
Background We hypothesized that single nucleotide polymorphisms (SNPs) located in
microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) …

Genetic markers: progress and potential for cardiovascular disease

GH Gibbons, CC Liew, MO Goodarzi, JI Rotter… - Circulation, 2004 - Am Heart Assoc
The recent completion of the Human Genome Project has provided an unprecedented
opportunity for researchers to identify high-risk patients and improve human health through …

[图书][B] Handbook of the vulnerable plaque

R Waksman, PW Serruys, J Schaar - 2007 - books.google.com
Since publication of the First Edition, advances in the diagnosis and prevention and
treatment strategies of the vulnerable plaque have necessitated this greatly expanded …

Genetic predisposition to coronary artery disease

MT Scheuner - Current opinion in cardiology, 2001 - journals.lww.com
Understanding the genetic basis of coronary artery disease (CAD) can improve
management and prevention. Family and twin studies, animal models and gene association …

Genetics of ultrasonographic carotid atherosclerosis

TA Manolio, E Boerwinkle, CJ O'Donnell… - … , and vascular biology, 2004 - Am Heart Assoc
The search for genes related to the cause of common complex disorders such as
cardiovascular disease has been frustrating, partly because of the many factors known to …