Portrait of a killer: Uncovering resistance mechanisms and global spread of Acinetobacter baumannii

AK Cain, M Hamidian - PLoS Pathogens, 2023 - journals.plos.org
Antibiotic resistance is a growing global concern in the field of medicine as it renders
bacterial infections difficult to treat and often more severe. Acinetobacter baumannii is a …

Antimicrobial resistance: two-component regulatory systems and multidrug efflux pumps

GV De Gaetano, G Lentini, A Famà, F Coppolino… - Antibiotics, 2023 - mdpi.com
The number of multidrug-resistant bacteria is rapidly spreading worldwide. Among the
various mechanisms determining resistance to antimicrobial agents, multidrug efflux pumps …

The multifaceted genus Acinetobacter: from infection to bioremediation

U Dahal, K Paul, S Gupta - Journal of Applied Microbiology, 2023 - academic.oup.com
Acinetobacter is a vast bacterial genus comprising of numerous species with variable
characteristics. The enigma associated with clinical strains that have been implicated in …

RND pumps across the genus Acinetobacter: AdeIJK is the universal efflux pump

EM Darby, VN Bavro, S Dunn… - Microbial …, 2023 - microbiologyresearch.org
Acinetobacter are generally soil-dwelling organisms that can also cause serious human
infections. A. baumannii is one of the most common causative agents of Acinetobacter …

Versatility of Stenotrophomonas maltophilia: Ecological roles of RND efflux pumps

A Chauviat, T Meyer, S Favre-Bonté - Heliyon, 2023 - cell.com
S. maltophilia is a widely distributed bacterium found in natural, anthropized and clinical
environments. The genome of this opportunistic pathogen of environmental origin includes a …

Structural analysis of resistance-nodulation cell division transporters

PA Klenotic, EW Yu - Microbiology and Molecular Biology Reviews, 2024 - Am Soc Microbiol
Infectious bacteria have both intrinsic and acquired mechanisms to combat harmful biocides
that enter the cell. Through adaptive pressures, many of these pathogens have become …

AadT, a new weapon in Acinetobacter's fight against antibiotics

V Naidu, B Shah, C Maher, IT Paulsen… - …, 2023 - microbiologyresearch.org
Genes encoding a novel multidrug efflux pump, AadT, from the Drug: H+ antiporter 2 family,
were discovered in Acinetobacter multidrug resistance plasmids. Here, we profiled the …

[HTML][HTML] Identification of essential genes that support fitness of Acinetobacter baumannii efflux pump overproducers in the presence of fluoroquinolone

E Hamami, W Huo, K Neal, I Neisewander, E Geisinger… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Acinetobacter baumannii is a nosocomial pathogen often associated with multidrug
resistance (MDR) infections. Fluoroquinolone resistance (FQR) due to drug target site …

[HTML][HTML] Identification of Determinants that Allow Maintenance of High-Level Fluoroquinolone Resistance in Acinetobacter baumannii

E Hamami, W Huo, J Hernandez-Bird, A Castaneda… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Acinetobacter baumannii is associated with multidrug resistant (MDR) infections in
healthcare settings, with fluoroquinolones such as ciprofloxacin being currently ineffective …

CRISPR/Cas9 介导的adeG 基因敲除大肠杆菌细菌模型的建立

朱恬仪, 孔桂美, 焦红梅, 郭停停, 乌日汗… - 生物技术 …, 2024 - biotech.aiijournal.com
[目的] 鲍曼不动杆菌(Acinetobacter baumannii, AB) 是引起医院内感染的重要条件致病菌之一,
耐药性AB 是目前防治的棘手问题. 细菌外排泵是引起耐药性的重要原因之一, 拟通过PCR …