The T-box riboswitch is a unique, RNA-based regulatory mechanism that modulates
expression of a wide variety of amino acid-related genes, predominantly in Firmicutes. RNAs …

T‐box riboswitches are a widespread class of structured noncoding RNAs in Gram‐positive
bacteria that regulate the expression of amino acid‐related genes. They form negative …

Amino acid availability in Gram-positive bacteria is monitored by T-box riboswitches. T-
boxes directly bind tRNAs, assess their aminoacylation state, and regulate the transcription …

In Gram-positive bacteria, T-box riboswitches control gene expression to maintain the
cellular pools of aminoacylated tRNAs essential for protein biosynthesis. Co-transcriptional …

T-box riboswitches are cis-regulatory RNA elements that regulate the expression of proteins
involved in amino acid biosynthesis and transport by binding to specific tRNAs and sensing …

T box riboswitches are RNA regulatory elements widely used by organisms in the phyla
Firmicutes and Actinobacteria to regulate expression of amino acid-related genes …

RNAs are prone to misfolding and are often more challenging to crystallize and phase than
proteins. Here, we demonstrate that tRNA fusion can streamline the crystallization and …

T-loops are highly abundant, structurally conserved five nucleotide motifs that facilitate long
range intra-and intermolecular interactions and function to stabilize the tertiary fold of RNA …

As the threat of antibiotic resistant infections and outbreaks looms, there has been a
reinvigorated interest in identifying new therapeutics to target alternative targets in species …

RNA mediated gene regulation has emerged as more and more important roles in central
dogma. It has expanded the complexity of gene regulation at multiple different aspects. A …