Pulmonary arterial hypertension (PAH) is a devastating disease that involves pulmonary
vasoconstriction, small vessel obliteration, large vessel thickening and obstruction, and …

There is nervous control of the heart by ATP as a cotransmitter in sympathetic,
parasympathetic, and sensory-motor nerves, as well as in intracardiac neurons. Centers in …

Transfusion-related acute lung injury (TRALI) can occur during or after a transfusion, and
remains a leading cause of transfusion-associated morbidity and mortality. TRALI is caused …

Deep vein thrombosis (DVT), caused by alterations in venous homeostasis, is the third most
common cause of cardiovascular mortality, however, key molecular determinants in venous …

Background Recent studies demonstrate that spatially restricted, local Ca2+ signals are key
regulators of endothelium‐dependent vasodilation in systemic circulation. There are drastic …

The distal lung provides an intricate structure for gas exchange in mammalian lungs.
Efficient gas exchange depends on the functional integrity of lung alveoli. The cells in the …

The concept of extracellular purinergic signaling was first proposed by Geoffrey Burnstock in
the early 1970s. Since then, extracellular ATP and its metabolites ADP and adenosine have …

Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-
protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the …

Abstract Adenosine 5′-triphosphate (ATP) is found in every cell of the human body where it
plays a critical role in cellular energetics and metabolism. ATP is released from cells under …

Previous studies have suggested that dysbiosis of the gut microbiota is associated with the
development of pulmonary hypertension (PH). In this study, we established a left pulmonary …