Methicillin-resistant Staphylococcus aureus (MRSA) infection is still a major global
healthcare problem. Of concern is S. aureus bacteremia, which exhibits high rates of …

Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Background The prevalence and effects of inappropriate empirical antibiotic therapy for
bloodstream infections are unclear. We aimed to establish the population-level burden …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Objective: The first 70 years of critical care can be considered a period of “industrial
revolution-like” advancement in terms of progressing the understanding and care of critical …

Antimicrobial resistance (AMR) is a global health crisis that poses a great threat to modern
medicine. Effective prevention strategies are urgently required to slow the emergence and …

The incidence of infections caused by bacteria that are resistant to antibiotics is constantly
increasing. In Europe alone, it has been estimated that each year about 33′ 000 deaths are …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

The recent development of commercial panel-based molecular diagnostics for the rapid
detection of pathogens in positive blood culture bottles, respiratory specimens, stool, and …

Objectives When bloodstream infections are caused by resistant bacteria, rapid
antimicrobial susceptibility testing (RAST) is important for adjustment of therapy. The …