Ontogeny of drug metabolizing enzymes in the neonate
Fetal exposure to xenobiotics is modulated to a considerable degree by the metabolic
capabilities of the mother and the placenta. However, once liberated from the uterine …
capabilities of the mother and the placenta. However, once liberated from the uterine …
Facilitation of drug evaluation in children by population methods and modelling
M Tod, V Jullien, G Pons - Clinical pharmacokinetics, 2008 - Springer
The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …
populations, the latter being particularly heterogeneous. These differences in …
Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children
TN Johnson, A Rostami-Hodjegan, GT Tucker - Clinical pharmacokinetics, 2006 - Springer
Background Prediction of the exposure of neonates, infants and children to xenobiotics is
likely to be more successful using physiologically based pharmacokinetic models than …
likely to be more successful using physiologically based pharmacokinetic models than …
Pharmacokinetic properties of infliximab in children and adults with Crohn's disease: a retrospective analysis of data from 2 phase III clinical trials
AA Fasanmade, OJ Adedokun, M Blank, H Zhou… - Clinical …, 2011 - Elsevier
BACKGROUND: Infliximab is a chimeric monoclonal antibody against TNFα. The
pharmacokinetic (PK) properties of infliximab have been studied in several adult patient …
pharmacokinetic (PK) properties of infliximab have been studied in several adult patient …
Guidelines for the determination of brain death in infants and children: an update of the 1987 Task Force recommendations
TA Nakagawa, S Ashwal, M Mathur, M Mysore… - …, 2011 - publications.aap.org
This Clinical Report was retired October 2023. OBJECTIVE: To review and revise the 1987
pediatric brain death guidelines. METHODS: Relevant literature was reviewed …
pediatric brain death guidelines. METHODS: Relevant literature was reviewed …
Consensus guidelines on sedation and analgesia in critically ill children
S Playfor, I Jenkins, C Boyles, I Choonara… - Intensive care …, 2006 - Springer
Abstract Objective The United Kingdom Paediatric Intensive Care Society Sedation,
Analgesia and Neuromuscular Blockade Working Group is a multi-disciplinary expert panel …
Analgesia and Neuromuscular Blockade Working Group is a multi-disciplinary expert panel …
Meta‐analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modeling
VV Upreti, JL Wahlstrom - The Journal of Clinical …, 2016 - Wiley Online Library
The accurate prediction of pharmacokinetics (PK) is fundamental to underwriting safety and
efficacy in pediatric clinical trials; age‐dependent PK may be observed with pediatrics …
efficacy in pediatric clinical trials; age‐dependent PK may be observed with pediatrics …
Scaling clearance in paediatric pharmacokinetics: all models are wrong, which are useful?
E Germovsek, CIS Barker, M Sharland… - British journal of …, 2017 - Wiley Online Library
Linked Articles This article is commented on in the editorial by Holford NHG and Anderson
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …
BJ. Why standards are useful for predicting doses. Br J Clin Pharmacol 2017; 83: 685–7. doi …
Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial
A Mpimbaza, G Ndeezi, S Staedke, PJ Rosenthal… - …, 2008 - publications.aap.org
OBJECTIVE. Our goal was to compare the efficacy and safety of buccal midazolam with
rectal diazepam in the treatment of prolonged seizures in Ugandan children. METHODS …
rectal diazepam in the treatment of prolonged seizures in Ugandan children. METHODS …
Population pharmacokinetic studies in pediatrics: issues in design and analysis
B Meibohm, S Läer, JC Panetta, JS Barrett - The AAPS journal, 2005 - Springer
The current review addresses the following 3 frequently encountered challenges in the
design and analysis of population pharmacokinetic studies in pediatrics:(1) body size …
design and analysis of population pharmacokinetic studies in pediatrics:(1) body size …