Bacterial transition metal homoeostasis or simply 'metallostasis' describes the process by
which cells control the intracellular availability of functionally required metal cofactors, from …

[NiFe]-hydrogenases catalyze the reversible conversion of hydrogen gas into protons and
electrons and are vital metabolic components of many species of bacteria and archaea. At …

Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a
major risk factor for the development of peptic ulcer disease and gastric cancer. Current …

First row d‐block metal ions serve as vital cofactors for numerous essential enzymes and are
therefore required nutrients for all forms of life. Despite this requirement, excess free …

[NiFe]-hydrogenase enzymes catalyze the reversible reduction of protons to molecular
hydrogen and serve as a vital component of the metabolism of many pathogens. The …

Hydrogenases and ureases play vital metabolic functions in all three domains of life.
However, nickel ions are cytotoxic because they can inactivate enzymes that require less …

Flavodoxins are small soluble electron transfer proteins widely present in bacteria and
absent in vertebrates. Flavodoxins participate in different metabolic pathways and, in some …

Maturation of urease involves post-translational insertion of nickel ions to form an active site
with a carbamylated lysine ligand and is assisted by urease accessory proteins UreD, UreE …

Helicobacter pylori colonizes the stomachs of greater than 50% of the world's human
population making it arguably one of the most successful bacterial pathogens. Chronic H …

Helicobacter pylori is a human bacterial pathogen that causes peptic ulcers and has been
designated a Class I carcinogen by the International Agency for Research on Cancer …