Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

We have applied an optical super-resolution technique based on single-molecule
localization to examine the peripheral distribution of a cardiac signaling protein, the …

In the current study, the three-dimensional (3D) topologies of dyadic clefts and associated
membrane organelles were mapped in mouse ventricular myocardium using electron …

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca2+ release
from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to …

Sarcoplasmic reticulum (SR) Ca2+ leak is an important component of cardiac Ca2+
signalling. Together with the SR Ca2+‐ATPase (SERCA)‐mediated Ca2+ uptake, diastolic …

Aims In atrial fibrillation (AF), abnormalities in Ca2+ release contribute to arrhythmia
generation and contractile dysfunction. We explore whether ryanodine receptor (RyR) …

We present what we believe to be a new mathematical model of Ca 2+ leak from the
sarcoplasmic reticulum (SR) in the heart. To our knowledge, it is the first to incorporate a …

It has been six years since the first reported link between mutations in the cardiac ryanodine
receptor Ca2+ release channel (RyR2) and catecholaminergic polymorphic ventricular …