Biologic therapies for severe asthma
GG Brusselle, GH Koppelman - New England Journal of …, 2022 - Mass Medical Soc
Biologic Therapies for Severe Asthma Patients with severe asthma are at increased risk for a
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …
decreased quality of life, fixed airway obstruction, hospitalization, and death. Biologics may …
The cytokines of asthma
BN Lambrecht, H Hammad, JV Fahy - Immunity, 2019 - cell.com
Asthma is a chronic inflammatory airway disease associated with type 2 cytokines
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …
interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus …
Cellular and molecular mechanisms of allergic asthma
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
worldwide. It is the most common chronic disease in children, affecting at least 30 million …
Interleukin-5 in the pathophysiology of severe asthma
C Pelaia, G Paoletti, F Puggioni, F Racca… - Frontiers in …, 2019 - frontiersin.org
Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival,
and degranulation of eosinophils. Indeed, during the last years, significant advances have …
and degranulation of eosinophils. Indeed, during the last years, significant advances have …
The immunology of asthma
BN Lambrecht, H Hammad - Nature immunology, 2015 - nature.com
Asthma is a common disease that affects 300 million people worldwide. Given the large
number of eosinophils in the airways of people with mild asthma, and verified by data from …
number of eosinophils in the airways of people with mild asthma, and verified by data from …
Japanese guidelines for adult asthma 2020
Y Nakamura, J Tamaoki, H Nagase… - Allergology …, 2020 - jstage.jst.go.jp
abstract Bronchial asthma is characterized by chronic airway inflammation, which manifests
clinically as variable airway narrowing (wheezes and dyspnea) and cough. Long-standing …
clinically as variable airway narrowing (wheezes and dyspnea) and cough. Long-standing …
The biology of eosinophils and their role in asthma
CN McBrien, A Menzies-Gow - Frontiers in medicine, 2017 - frontiersin.org
This review will describe the structure and function of the eosinophil. The roles of several
relevant cell surface molecules and receptors will be discussed. We will also explore the …
relevant cell surface molecules and receptors will be discussed. We will also explore the …
[HTML][HTML] Reslizumab for inadequately controlled asthma with elevated blood eosinophil levels: a randomized phase 3 study
L Bjermer, C Lemiere, J Maspero, S Weiss, J Zangrilli… - Chest, 2016 - Elsevier
Background This phase 3 study further characterizes the efficacy and safety of reslizumab (a
humanized anti-IL-5 monoclonal antibody) in patients aged 12 to 75 years with asthma …
humanized anti-IL-5 monoclonal antibody) in patients aged 12 to 75 years with asthma …
Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia
Background In patients with severe eosinophilic asthma, local maturation rather than
systemic recruitment of mature cells might contribute to persistent airway eosinophilia …
systemic recruitment of mature cells might contribute to persistent airway eosinophilia …
[HTML][HTML] Phase 3 study of reslizumab in patients with poorly controlled asthma: effects across a broad range of eosinophil counts
J Corren, S Weinstein, L Janka, J Zangrilli, M Garin - Chest, 2016 - Elsevier
Background IL-5, a mediator of eosinophil activity, is an important potential treatment target
in patients with uncontrolled asthma. The efficacy of reslizumab, a humanized anti-human IL …
in patients with uncontrolled asthma. The efficacy of reslizumab, a humanized anti-human IL …