[HTML][HTML] Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
BF Haynes, K Wiehe, SM Alam… - Current Opinion in …, 2023 - journals.lww.com
Recent progress has been made in both immunogen design and in achieving bnAb B cell
lineage induction in animal models and now in human clinical trials. With continued …
lineage induction in animal models and now in human clinical trials. With continued …
Alterations in gp120 glycans or the gp41 fusion peptide-proximal region modulate the stability of the human immunodeficiency virus (HIV-1) envelope glycoprotein …
The human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer mediates
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
entry into host cells by binding receptors, CD4 and CCR5/CXCR4, and fusing the viral and …
[HTML][HTML] Structure-function analyses reveal key molecular determinants of HIV-1 CRF01_AE resistance to the entry inhibitor temsavir
The HIV-1 entry inhibitor temsavir prevents the viral receptor CD4 (cluster of differentiation 4)
from interacting with the envelope glycoprotein (Env) and blocks its conformational changes …
from interacting with the envelope glycoprotein (Env) and blocks its conformational changes …
V3 tip determinants of susceptibility to inhibition by CD4-mimetic compounds in natural clade A human immunodeficiency virus (HIV-1) envelope glycoproteins
ABSTRACT CD4-mimetic compounds (CD4mcs) bind the human immunodeficiency virus
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
(HIV-1) gp120 exterior envelope glycoprotein (Env) and compete for binding to CD4, the …
[HTML][HTML] Higher HIV-1 Env gp120-specific antibody-dependent cellular cytotoxicity (ADCC) activity is associated with lower levels of defective HIV-1 provirus
R Yucha, ML Litchford, CS Fish, ZA Yaffe… - Viruses, 2023 - mdpi.com
A cure for HIV-1 (HIV) remains unrealized due to a reservoir of latently infected cells that
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
persist during antiretroviral therapy (ART), with reservoir size associated with adverse health …
Conformations of human immunodeficiency virus envelope glycoproteins in detergents and styrene-maleic acid lipid particles
The mature human immunodeficiency virus (HIV) envelope glycoprotein (Env) trimer, which
consists of noncovalently associated gp120 exterior and gp41 transmembrane subunits …
consists of noncovalently associated gp120 exterior and gp41 transmembrane subunits …
Stoichiometry for entry and binding properties of the Env protein of R5 T cell-tropic HIV-1 and its evolutionary variant of macrophage-tropic HIV-1
X Bonner, A Sondgeroth, A McCue, N Nicely… - Mbio, 2024 - Am Soc Microbiol
Human immunodeficiency virus type 1 typically requires a high density of CD4 for efficient
entry as a mechanism to target CD4+ T cells (T-tropic), with CCR5 being used most often as …
entry as a mechanism to target CD4+ T cells (T-tropic), with CCR5 being used most often as …
Inhibition of human immunodeficiency virus (HIV-1) infectivity by expression of poorly or broadly neutralizing antibodies against Env in virus-producing cells
The human immunodeficiency virus (HIV-1) envelope (Env) glycoprotein precursor (gp160)
trimerizes, is modified by high-mannose glycans in the endoplasmic reticulum, and is …
trimerizes, is modified by high-mannose glycans in the endoplasmic reticulum, and is …
Membrane HIV-1 Envelope Glycoproteins Stabilized More Strongly in a Pretriggered Conformation than Natural Virus Envs
The pretriggered conformation of the human immunodeficiency virus (HIV-1) envelope
glycoprotein (Env) trimer ((gp120/gp41) 3) is targeted by virus entry inhibitors and broadly …
glycoprotein (Env) trimer ((gp120/gp41) 3) is targeted by virus entry inhibitors and broadly …
Conformations of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins in Detergents and Styrene-Maleic Acid Lipid Particles (SMALPs)
The mature human immunodeficiency virus (HIV-1) envelope glycoprotein (Env) trimer,
which consists of non-covalently associated gp120 exterior and gp41 transmembrane …
which consists of non-covalently associated gp120 exterior and gp41 transmembrane …