Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …

Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune
hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or …

Interferon-γ (IFNγ) is a pleiotropic cytokine with multiple effects on the inflammatory
response and on innate and adaptive immunity. Overproduction of IFNγ underlies several …

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS)
are life-threatening hyperferritinemic systemic inflammatory disorders. Although profound …

The article focuses on cytokine storm syndrome which is a diverse set of conditions unified
by a clinical phenotype of systemic inflammation, multi-organ failure and hyperferritinemia …

Abstract Interleukin (IL)-18 is a member of the IL-1 family of cytokines with pleiotropic and
potent pro-inflammatory activities that are tightly controlled at the level of production and in …

The pathogenesis of autoimmunity remains to be fully elucidated, although the contribution
of genetic and environmental factors is generally recognized. Despite autoimmune …

Adult-onset Still's disease (AoSD) is a rare systemic autoinflammatory disease characterized
by arthritis, spiking fever, skin rash and elevated ferritin levels. The reason behind the …

COVID-19 is characterised by a broad spectrum of clinical and pathological features. Natural
killer (NK) cells play an important role in innate immune responses to viral infections. Here …

Neutrophils are key pathogen exterminators of the innate immune system endowed with
oxidative and non-oxidative defense mechanisms. More recently, a more complex role for …