Alpha-synuclein (α-syn) is localized in cellular organelles of most neurons, but many of its
physiological functions are only partially understood. α-syn accumulation is associated with …

In the past two decades, mutations in multiple genes have been linked to autosomal
dominant or recessive forms of monogenic Parkinson's disease (PD). Collectively, these …

About 60 years ago, the discovery of a deficiency of dopamine in the nigro-striatal system
led to a variety of symptomatic therapeutic strategies to supplement dopamine and to …

DJ-1 is a multifunctional protein associated with pathomechanisms implicated in different
chronic diseases including neurodegeneration, cancer and diabetes. Several of the …

Background Parkinson's disease (PD) is one of the most common neurodegenerative
diseases in the world. Mitophagy has been implicated in PD etiology for decades and its …

Many neurodegenerative and inherited metabolic diseases frequently compromise nervous
system function, and mitochondrial dysfunction and oxidative stress have been implicated as …

Neurodegeneration leads to multiple early changes in cognitive, emotional, and social
behaviours and ultimately progresses to dementia. The dysregulation of calcium is one of …

Abstract Background Early onset Parkinson's disease is caused by variants in PINK1, parkin,
and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but …

Amyotrophic lateral sclerosis (ALS) is an adult-onset disease which causes the progressive
degeneration of cortical and spinal motoneurons, leading to death a few years after the first …

Chlorpyrifos (CPF) is an organophosphate insecticide used to control pests on a variety of
food and feed crops. In mammals, maternal exposure to CPF has been reported to induce …