Examining horizontal gene transfer in microbial communities

IL Brito - Nature Reviews Microbiology, 2021 - nature.com
Bacteria acquire novel DNA through horizontal gene transfer (HGT), a process that enables
an organism to rapidly adapt to changing environmental conditions, provides a competitive …

Mutualistic interplay between bacteriophages and bacteria in the human gut

AN Shkoporov, CJ Turkington, C Hill - Nature Reviews Microbiology, 2022 - nature.com
Bacteriophages (phages) are often described as obligate predators of their bacterial hosts,
and phage predation is one of the leading forces controlling the density and distribution of …

High-throughput, single-microbe genomics with strain resolution, applied to a human gut microbiome

W Zheng, S Zhao, Y Yin, H Zhang, DM Needham… - Science, 2022 - science.org
Characterizing complex microbial communities with single-cell resolution has been a long-
standing goal of microbiology. We present Microbe-seq, a high-throughput method that …

Viruses interact with hosts that span distantly related microbial domains in dense hydrothermal mats

Y Hwang, S Roux, C Coclet, SJE Krause… - Nature Microbiology, 2023 - nature.com
Many microbes in nature reside in dense, metabolically interdependent communities. We
investigated the nature and extent of microbe-virus interactions in relation to microbial …

Revisiting the rules of life for viruses of microorganisms

AMS Correa, C Howard-Varona, SR Coy… - Nature Reviews …, 2021 - nature.com
Viruses that infect microbial hosts have traditionally been studied in laboratory settings with
a focus on either obligate lysis or persistent lysogeny. In the environment, these infection …

Single-cell approaches in human microbiome research

V Lloréns-Rico, JA Simcock, GRB Huys, J Raes - Cell, 2022 - cell.com
Microbial culturing and meta-omic profiling technologies have significantly advanced our
understanding of the taxonomic and functional variation of the human microbiome and its …

Extensive gut virome variation and its associations with host and environmental factors in a population-level cohort

S Nishijima, N Nagata, Y Kiguchi, Y Kojima… - Nature …, 2022 - nature.com
Indigenous bacteriophage communities (virome) in the human gut have a huge impact on
the structure and function of gut bacterial communities (bacteriome), but virome variation at a …

Gut virome profiling identifies a widespread bacteriophage family associated with metabolic syndrome

PA de Jonge, K Wortelboer, TPM Scheithauer… - Nature …, 2022 - nature.com
There is significant interest in altering the course of cardiometabolic disease development
via gut microbiomes. Nevertheless, the highly abundant phage members of the complex gut …

Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

Resolving the structure of phage–bacteria interactions in the context of natural diversity

KM Kauffman, WK Chang, JM Brown… - Nature …, 2022 - nature.com
Microbial communities are shaped by viral predators. Yet, resolving which viruses (phages)
and bacteria are interacting is a major challenge in the context of natural levels of microbial …