The poly-l-proline type II (PPII) helix in recent years has emerged clearly as a structural class
not only of fibrillar proteins (in collagen, PPII is a dominant conformation) but also of the …

Lacasses are multicopper oxidases that can catalyze aromatic and non-aromatic
compounds concomitantly with reduction of molecular oxygen to water. Fungal laccases …

Highlights•The polyproline II helix is omnipresent.•Role of proline in stability of PPII helix and
its interactions.•Specific mechanisms work in PPII structural organization and …

Protein backbone torsion angles (Phi) and (Psi) involve two rotation angles rotating around
the Cα-N bond (Phi) and the Cα-C bond (Psi). Due to the planarity of the linked rigid peptide …

For the past 50 years, the Ramachandran map has been used effectively to study the protein
structure and folding. However, though extensive analysis has been done on dihedral angle …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a+ sense single-strand
RNA virus. The virus has four major surface proteins: spike (S), envelope (E), membrane …

Protein folding has been a major area of research for many years. Nonetheless, the
mechanisms leading to the formation of an active biological fold are still not fully …

One reason why ab initio protein structure predictors do not perform very well is their inability
to reliably identify long-range interactions between amino acids. To achieve reliable long …

The development of computational methods to accurately model three-dimensional protein
structures from sequences of amino acid residues is becoming increasingly important to the …

Bioinformatics or computational biology is a multidisciplinary research area that combines
molecular biology, computer science, and mathematics. Its aims are to organize, utilize and …