The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Orofacial clefts are common birth defects and can occur as isolated, nonsyndromic events or
as part of Mendelian syndromes. There is substantial phenotypic diversity in individuals with …

GABA-containing interneurons are crucial to both the development and function of the
cerebral cortex. Unlike cortical projection neurons, which have a relatively conserved set of …

We have assessed the efficacy of the recently developed CRISPR/Cas (clustered regularly
interspaced short palindromic repeats/CRISPR‐associated) system for genome modification …

Transcriptional control is a major mechanism for regulating gene expression. The complex
machinery required to effect this control is still emerging from functional and evolutionary …

▪ Abstract This review provides a synthesis that combines data from classical
experimentation and recent advances in our understanding of early eye development …

to the Second Edition here have been significant changes in pediatric Chapter 56 by Maya
Eibschitz-Tsimhoni, MD, is a T ophthalmology and strabismus since the first wonderful …

In vertebrate embryos, formation of anterior neural structures requires suppression of Wnt
signals emanating from the paraxial mesoderm and midbrain territory. In Six3−/− mice, the …

Cranial placodes are focal regions of thickened ectoderm in the head of vertebrate embryos
that give rise to a wide variety of cell types, including elements of the paired sense organs …

The head is anatomically the most sophisticated part of the body and its evolution was
fundamental to the origin of vertebrates; understanding its development is a formidable …