Cell biology of T cell receptor expression and regulation
A Alcover, B Alarcón, V Di Bartolo - Annual review of …, 2018 - annualreviews.org
T cell receptors (TCRs) are protein complexes formed by six different polypeptides. In most T
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …
cells, TCRs are composed of αβ subunits displaying immunoglobulin-like variable domains …
T cell receptor signalling networks: branched, diversified and bounded
RJ Brownlie, R Zamoyska - Nature Reviews Immunology, 2013 - nature.com
Engagement of antigen-specific T cell receptors (TCRs) is a prerequisite for T cell activation.
Acquisition of appropriate effector T cell function requires the participation of multiple signals …
Acquisition of appropriate effector T cell function requires the participation of multiple signals …
Membrane-anchored DNA nanojunctions enable closer antigen-presenting cell–T-cell contact in elevated T-cell receptor triggering
How the engagement of a T-cell receptor to antigenic peptide-loaded major
histocompatibility complex on antigen-presenting cells (APCs) initiates intracellular …
histocompatibility complex on antigen-presenting cells (APCs) initiates intracellular …
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
T Yokosuka, M Takamatsu… - Journal of Experimental …, 2012 - rupress.org
Programmed cell death 1 (PD-1) is a negative costimulatory receptor critical for the
suppression of T cell activation in vitro and in vivo. Single cell imaging elucidated a …
suppression of T cell activation in vitro and in vivo. Single cell imaging elucidated a …
[HTML][HTML] The 2015 super-resolution microscopy roadmap
Far-field optical microscopy using focused light is an important tool in a number of scientific
disciplines including chemical,(bio) physical and biomedical research, particularly with …
disciplines including chemical,(bio) physical and biomedical research, particularly with …
DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity
T cells are triggered when the T-cell receptor (TCR) encounters its antigenic ligand, the
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …
peptide-major histocompatibility complex (pMHC), on the surface of antigen presenting cells …
Initiation of T cell signaling by CD45 segregation at'close contacts'
It has been proposed that the local segregation of kinases and the tyrosine phosphatase
CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs …
CD45 underpins T cell antigen receptor (TCR) triggering, but how such segregation occurs …
T cell activation
JE Smith-Garvin, GA Koretzky… - Annual review of …, 2009 - annualreviews.org
This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …
[HTML][HTML] The interplay between membrane topology and mechanical forces in regulating T cell receptor activity
T cells are critically important for host defense against infections. T cell activation is specific
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
because signal initiation requires T cell receptor (TCR) recognition of foreign antigen …
Insights into the initiation of TCR signaling
AK Chakraborty, A Weiss - Nature immunology, 2014 - nature.com
The initiation of T cell antigen receptor signaling is a key step that can result in T cell
activation and the orchestration of an adaptive immune response. Early events in T cell …
activation and the orchestration of an adaptive immune response. Early events in T cell …