Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the
most important. It is crucial to the very process that enables the chambers of the heart to …

The Na+/Ca2+ exchanger, an ion transport protein, is expressed in the plasma membrane
(PM) of virtually all animal cells. It extrudes Ca2+ in parallel with the PM ATP-driven Ca2+ …

The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

Mutations in ion channels involved in the generation and termination of action potentials
constitute a family of molecular defects that underlie fatal cardiac arrhythmias in inherited …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

Cardiotonic steroids (CTS), long used to treat heart failure, are endogenously produced in
mammals. Among them are the hydrophilic cardenolide ouabain and the more hydrophobic …

▪ Abstract Plasma membrane Na+-Ca2+ exchange is an essential component of Ca2+
signaling pathways in several tissues. Activity is especially high in the heart where the …

Cardiac glycosides have played a prominent role in the therapy of congestive heart failure
since William Withering codified their use in his late 18th century monograph on the efficacy …

It is well accepted that inhibition of the Na, K-ATPase in the heart, through effects on the
Na/Ca exchanger, raises the intracellular Ca 2+ concentration and strengthens cardiac …