Molecular regulations of circadian rhythm and implications for physiology and diseases

F Fagiani, D Di Marino, A Romagnoli… - Signal transduction and …, 2022 - nature.com
The term “circadian rhythms” describes endogenous oscillations with ca. 24-h period
associated with the earth's daily rotation and light/dark cycle. Such rhythms reflect the …

The functional and clinical significance of the 24-hour rhythm of circulating glucocorticoids

H Oster, E Challet, V Ott, E Arvat, ER de Kloet… - Endocrine …, 2017 - academic.oup.com
Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

New insights into the circadian rhythm and its related diseases

Y Xie, Q Tang, G Chen, M Xie, S Yu, J Zhao… - Frontiers in …, 2019 - frontiersin.org
Circadian rhythms (CR) are a series of endogenous autonomous oscillators generated by
the molecular circadian clock which acting on coordinating internal time with the external …

Circadian rhythms, time-restricted feeding, and healthy aging

ENC Manoogian, S Panda - Ageing research reviews, 2017 - Elsevier
Circadian rhythms optimize physiology and health by temporally coordinating cellular
function, tissue function, and behavior. These endogenous rhythms dampen with age and …

Stress & sleep: A relationship lasting a lifetime

VL Martire, D Caruso, L Palagini, G Zoccoli… - Neuroscience & …, 2020 - Elsevier
Stress is an adaptative response aimed at restoring body homeostasis. The classical
neuroendocrine stress response involving the activation of the hypothalamic-pituitary …

[HTML][HTML] Stress: endocrine physiology and pathophysiology

C Tsigos, I Kyrou, E Kassi, GP Chrousos - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic
adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and …

Central and peripheral circadian clocks in mammals

JA Mohawk, CB Green… - Annual review of …, 2012 - annualreviews.org
The circadian system of mammals is composed of a hierarchy of oscillators that function at
the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell …

The mammalian circadian clock and its entrainment by stress and exercise

Y Tahara, S Aoyama, S Shibata - The Journal of Physiological Sciences, 2017 - Springer
The mammalian circadian clock regulates day–night fluctuations in various physiological
processes. The circadian clock consists of the central clock in the suprachiasmatic nucleus …

Alcoholism: a systems approach from molecular physiology to addictive behavior

R Spanagel - Physiological reviews, 2009 - journals.physiology.org
Alcohol consumption is an integral part of daily life in many societies. The benefits
associated with the production, sale, and use of alcoholic beverages come at an enormous …

Circadian rhythms in the hypothalamo–pituitary–adrenal (HPA) axis

A Kalsbeek, R Van der Spek, J Lei, E Endert… - Molecular and cellular …, 2012 - Elsevier
The pronounced daily variation in the release of adrenal hormones has been at the heart of
the deciphering and understanding of the circadian timing system. Indeed, the first …