Proton pump inhibitors have an excellent safety profile and have become one of the most
commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes …

Proton pump (H+/K+–adenosine triphosphatase) inhibitors (PPIs) are widely used to treat
patients with acid-related disorders because they are generally perceived to be safe and …

This thoroughly revised and updated reference addresses the drugs and chemicals causing
malformations and congenital anomalies in the human fetus-comprehensively reviewing …

BACKGROUND Nausea and vomiting of pregnancy (NVP) occurs in up to 80% of pregnant
women, but its association with birth outcomes is not clear. Several medications are used for …

Gastric acid secretion is a complex phenomenon under nervous and hormonal influence.
The stimulation of proton pump (H+, K+-ATPase) in the parietal cell represents the final step …

OBJECTIVES: Heartburn and acid reflux are common medical disorders in pregnancy and
can result in serious discomfort and complications. Furthermore, some pregnant women also …

Background Symptoms of gastroesophageal reflux are common in pregnancy, but there are
limited data on the risk of birth defects associated with exposure to proton-pump inhibitors …

Heartburn is estimated to occur in 30% to 50% of pregnancies, with the incidence
approaching 80% in some populations [1]. Uncommonly, it represents an exacerbation of …

Identification of chemicals that pose a hazard to the developing nervous system is the first
step in reducing human exposure and preventing health risks to infants and children. In …

Despite evidence of fetal safety, most antiemetics are contraindicated in pregnancy. We
summarise a risk-benefit analysis of the literature on safety and effectiveness of …