Antiinflammatory potential of medicinal plants: A source for therapeutic secondary metabolites

N Bernstein, M Akram, M Daniyal, H Koltai… - Advances in …, 2018 - Elsevier
Plants containing natural products have been used worldwide in traditional medicine since
antiquity and are a source of potential and powerful drugs. The potential of higher plants as …

The therapeutic value of alstonine: An updated review

F Olawale, TL Adetunji, AE Adetunji, O Iwaloye… - South African Journal of …, 2023 - Elsevier
Alstonine is an indole alkaloid found abundantly in some traditional plants. In some parts of
the world, including Nigeria and India, plants containing alstonine have been used to cure …

Rural-urban differences in household treatment-seeking behaviour for suspected malaria in children at Bata District, Equatorial Guinea

M Romay-Barja, I Jarrin, P Ncogo, G Nseng… - PloS one, 2015 - journals.plos.org
Background Malaria remains a major cause of morbidity and mortality among children under
five years old in Equatorial Guinea. However, little is known about the community …

[HTML][HTML] Neuroprotection by Alstonia boonei De Wild., Anacardium occidentale L., Azadirachta indica A. Juss. and Mangifera indica L.

VU Iwuanyanwu, OW Banjo, KT Babalola… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacology relevance Alstonia boonei De Wild.(stem bark), Anacardium
occidentale L.(stem bark), Azadirachta indica A. Juss (leaves), Enantia chlorantha Oliv.(stem …

A novel compound purified from Alstonia boonei inhibits Plasmodium falciparum lactate dehydrogenase and plasmepsin II

JO Olanlokun, AF Olotu, OM David… - Journal of …, 2019 - Taylor & Francis
Malarial infection is a disease that has defied many therapeutic and chemopreventive
interventions due to persistent resistance to currently available drugs. This is driven by the …

[HTML][HTML] Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models

S Owumi, JO Olanlokun, B Wu, AM Duro-Ladipo… - Molecules, 2024 - mdpi.com
Agunmu (ground herbal medicine) is a form of West African traditional medicine consisting
of a cocktail of herbs. The goal of this study is to evaluate a formulation of Agunmu made …

[PDF][PDF] Toxicology of solvent extract and fractions of Alstonia boonei (DC.) Wild stem bark in Rats

OJ Olanlokun, OO Olorunsogo - Journal of herbmed …, 2018 - herbmedpharmacol.com
Introduction: Toxic effects arising from the use of medicinal herbs have been frequently
overshadowed by the therapeutic efficacy of phytomedicines. This study was carried out to …

Betulinic acid purified from Alstonia boonei inhibits folate biosynthesis in malarial Plasmodium, enhances mitochondrial pore opening and F1F0 ATPase in mice

JO Olanlokun, PO Okoro, OS Lawal, O Bodede… - Journal of Molecular …, 2021 - Elsevier
Activity-guided assay of antimalarial properties of Alstonia boonei led to the purification of
betulinic acid from the chloroform fraction of the methanol stem bark extract. The structure …

[PDF][PDF] Effects of vacuum liquid chromatography (chloroform) fraction of the stem bark of Alstonia boonei on mitochondrial membrane permeability transition pore

OJ Olanlokun, TO Oyebode, OO Olorunsogo - J. Basic Clin. Pharm, 2017 - academia.edu
ABSTRACT Background: The Mitochondrial Membrane Permeability Transition (MMPT)
pore is an important target for the development of cytotoxic drugs because the release of …

Evaluation of In vivo Antiplasmodial Activity of the Methanol Root Bark Extract and Fractions of Bombax costatum (Bombacacea) in Plasmodium berghei-Infected Mice.

BH Ali, I Mohammed, MA Muhammed… - Tropical Journal of …, 2022 - search.ebscohost.com
Malarial infection is a disease that has defied many therapeutic and chemopreventive
interventions due to persistent resistance to currently available drugs. This has led to the …