Inside the diabetic brain: role of different players involved in cognitive decline

JM Gaspar, FI Baptista, MP Macedo… - ACS chemical …, 2016 - ACS Publications
Diabetes mellitus is the most common metabolic disease, and its prevalence is increasing. A
growing body of evidence, both in animal models and epidemiological studies, has …

Association between diabetes, diabetic retinopathy, and glaucoma

Y Li, W Mitchell, T Elze, N Zebardast - Current Diabetes Reports, 2021 - Springer
Abstract Purpose of Review The strength of the relationship between diabetes, diabetic
retinopathy (DR), and glaucoma remains controversial. We review evidence supporting and …

[HTML][HTML] Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers

C Carvalho, MS Santos, CR Oliveira… - Biochimica et Biophysica …, 2015 - Elsevier
We aimed to investigate mitochondrial function, biogenesis and autophagy in the brain of
type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and …

[HTML][HTML] Integrative biology of extracellular vesicles in diabetes mellitus and diabetic complications

J Liu, Y Zhang, Y Tian, W Huang, N Tong, X Fu - Theranostics, 2022 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is a chronic systemic disease with increasing prevalence globally.
An important aspect of diabetic pathogenesis is cellular crosstalk and information exchange …

[HTML][HTML] Neurodegeneration in diabetic retinopathy: potential for novel therapies

AJ Barber, B Baccouche - Vision research, 2017 - Elsevier
The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …

Neurovascular unit: a new target for treating early stages of diabetic retinopathy

R Simó, O Simó-Servat, P Bogdanov, C Hernández - Pharmaceutics, 2021 - mdpi.com
The concept of diabetic retinopathy as a microvascular disease has evolved and is now
considered a more complex diabetic complication in which neurovascular unit impairment …

Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice

JMN Duarte, PM Agostinho, RA Carvalho, RA Cunha - PLoS one, 2012 - journals.plos.org
Diabetic conditions are associated with modified brain function, namely with cognitive
deficits, through largely undetermined processes. More than understanding the underlying …

Targeted pharmacotherapy against neurodegeneration and neuroinflammation in early diabetic retinopathy

KD Rolev, X Shu, Y Ying - Neuropharmacology, 2021 - Elsevier
Diabetic retinopathy (DR), the most frequent complication of diabetes, is one of the leading
causes of irreversible blindness in working-age adults and has traditionally been regarded …

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

H Zhu, W Zhang, Y Zhao, X Shu, W Wang… - Molecular …, 2018 - Springer
Background Although diabetic retinopathy (DR) has long been considered as a
microvascular disorder, mounting evidence suggests that diabetic retinal …

The pathogenesis and therapeutic approaches of diabetic neuropathy in the retina

T Oshitari - International journal of molecular sciences, 2021 - mdpi.com
Diabetic retinopathy is a major retinal disease and a leading cause of blindness in the world.
Diabetic retinopathy is a neurovascular disease that is associated with disturbances of the …