Therapeutic strategies targeting connexins
The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …
Astrocyte networks as therapeutic targets in glaucomatous neurodegeneration
Astrocytes are intimately involved in the response to neurodegenerative stress and have
become an attractive target for the development of neuroprotective therapies. However …
become an attractive target for the development of neuroprotective therapies. However …
The left-right Pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine
The dorsal mesentery (DM) is the major conduit for blood and lymphatic vessels in the gut.
The mechanisms underlying their morphogenesis are challenging to study and remain …
The mechanisms underlying their morphogenesis are challenging to study and remain …
Impact of astroglial connexins on modafinil pharmacological properties
A Duchêne, M Perier, Y Zhao, X Liu, J Thomasson… - Sleep, 2016 - academic.oup.com
Abstract Study Objectives: Modafinil is a non-amphetaminic wake-promoting compound
used as therapy against sleepiness and narcolepsy. Its mode of action is complex, but …
used as therapy against sleepiness and narcolepsy. Its mode of action is complex, but …
Connexin-dependent neuroglial networking as a new therapeutic target
Astrocytes and neurons dynamically interact during physiological processes, and it is now
widely accepted that they are both organized in plastic and tightly regulated networks …
widely accepted that they are both organized in plastic and tightly regulated networks …
Connexin channel modulators and their mechanisms of action
VK Verselis, M Srinivas - Neuropharmacology, 2013 - Elsevier
Gap junction channels and hemichannels formed by the connexin family of proteins play
important roles in many aspects of tissue homeostasis in the brain and in other organs. In …
important roles in many aspects of tissue homeostasis in the brain and in other organs. In …
[HTML][HTML] Connexins as therapeutic targets in neurological and neuropsychiatric disorders
M Charvériat, F Mouthon, W Rein… - Biochimica et Biophysica …, 2021 - Elsevier
Astrocytes represent the reticular part of the central nervous system; gap junctions formed by
connexins Cx43, Cx30-and Cx26 provide for homocellular astrocyte-astrocyte coupling …
connexins Cx43, Cx30-and Cx26 provide for homocellular astrocyte-astrocyte coupling …
Improved multiparametric scrape loading-dye transfer assay for a simultaneous high-throughput analysis of gap junctional intercellular communication, cell density …
A Dydowiczová, O Brózman, P Babica… - Scientific Reports, 2020 - nature.com
Gap junctional intercellular communication (GJIC) is a vital cellular process required for
maintenance of tissue homeostasis. In vitro assessment of GJIC represents valuable …
maintenance of tissue homeostasis. In vitro assessment of GJIC represents valuable …
Targeting connexins: possible game changer in managing neuropathic pain?
Neuropathic pain is a chronic debilitating condition caused by nerve injury or a variety of
diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the …
diseases. At the core of neuropathic pain lies the aberrant neuronal excitability in the …
Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins …
F Sauvet, M Erblang, D Gomez‐Merino… - British journal of …, 2019 - Wiley Online Library
Aims: THN102 is a novel combination of modafinil and low‐dose flecainide, targeting glial
connexin activity to modulate modafinil effects. We investigated THN102 efficacy compared …
connexin activity to modulate modafinil effects. We investigated THN102 efficacy compared …