The STING1 network regulates autophagy and cell death

R Zhang, R Kang, D Tang - Signal transduction and targeted therapy, 2021 - nature.com
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …

Medicinal Potential of Garcinia Species and Their Compounds

BLS Espirito Santo, LF Santana, WH Kato Junior… - Molecules, 2020 - mdpi.com
Garcinia is a genus of Clusiaceae, distributed throughout tropical Asia, Africa, New
Caledonia, Polynesia, and Brazil. Garcinia plants contain a broad range of biologically …

Bioactive compounds from mangosteen (Garcinia mangostana L.) as an antiviral agent via dual inhibitor mechanism against SARSCoV-2: an in silico approach

ANM Ansori, VD Kharisma, AA Parikesit… - Pharmacognosy …, 2022 - phcogj.com
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is the virus that causes
COVID-19 which is responsible for respiratory illness infection in humans. The virus was first …

[HTML][HTML] Ultrasound-assisted extraction, analysis and antioxidant activity of polysaccharide from the rinds of Garcinia mangostana L.

Z Tang, Y Wang, G Huang, H Huang - Ultrasonics Sonochemistry, 2023 - Elsevier
According to response surface methodology (RSM), the extraction conditions of ultrasound-
assisted extraction of polysaccharide from the rinds of Garcinia mangostana L.(GMRP) were …

[HTML][HTML] Ultrasonic/cellulase-assisted extraction of polysaccharide from Garcinia mangostana rinds and its carboxymethylated derivative

Z Tang, G Huang, H Huang - Ultrasonics Sonochemistry, 2023 - Elsevier
Response surface methodology was selected to explore the ultrasonic-assisted cellulase
extraction conditions of Garcinia mangostana rind polysaccharides (GMRPs), and the …

Xanthone biosynthetic pathway in plants: a review

J Remali, I Sahidin, WM Aizat - Frontiers in Plant Science, 2022 - frontiersin.org
Xanthones are secondary metabolites rich in structural diversity and possess a broad array
of pharmacological properties, such as antitumor, antidiabetic, and anti-microbes. These …

[HTML][HTML] Valorization of mangosteen,“The Queen of Fruits,” and new advances in postharvest and in food and engineering applications: A review

WM Aizat, FH Ahmad-Hashim, SNS Jaafar - Journal of Advanced Research, 2019 - Elsevier
One of the most prolific plants utilized in various applications is mangosteen (Garcinia
mangostana L.). Rich in potent bioactive compounds, such as xanthones, mangosteen is …

Current status and contemporary approaches to the discovery of antitumor agents from higher plants

G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …

Mangostanin, a Xanthone Derived from Garcinia mangostana Fruit, Exerts Protective and Reparative Effects on Oxidative Damage in Human Keratinocytes

M Abate, C Pagano, M Masullo, M Citro, S Pisanti… - Pharmaceuticals, 2022 - mdpi.com
The fruit of Garcinia mangostana (mangosteen) is known in ancient traditional Asian
medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer activities …

Pharmacological modulation of the STING pathway for cancer immunotherapy

G Berger, M Marloye, SE Lawler - Trends in molecular medicine, 2019 - cell.com
The advent of immunotherapy in recent years has shown the potential to revolutionize the
treatment of cancer. Unleashing antitumor T cell responses via immune checkpoint blockade …