Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

Significance: The molecular mechanism of aging is still vigorously debated, although a
general consensus exists that mitochondria are significantly involved in this process …

Possession of the ε4 allele of apolipoprotein E (APOE) is the major genetic risk factor for late-
onset Alzheimer's disease (AD). Although numerous hypotheses have been proposed, the …

Mitochondria, the energy stations of the cell, are the only extranuclear organelles, containing
their own (mitochondrial) DNA (mtDNA) and the protein synthesizing machinery. The …

Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson's
disease (PD) and genetic variation around LRRK2 contributes to risk of sporadic disease …

Accumulation and misfolding of the alpha-synuclein protein are core mechanisms in the
pathogenesis of Parkinson's disease. While the normal function of alpha-synuclein is mainly …

Abstract Background Early onset Parkinson's disease is caused by variants in PINK1, parkin,
and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but …

The mitochondrial mutator mouse is a well-established model of premature aging. In
addition to accelerated aging, these mice develop hypertrophic cardiomyopathy at~ 13 …

Mitochondria are central to metabolic homeostasis, and progressive mitochondrial defects
have diverse metabolic consequences that could drive distinct pathophysiological states …

Mutations in the DJ-1 gene cause autosomal recessive parkinsonism in humans. Several
mouse models of DJ-1 deficiency have been developed, but they do not have dopaminergic …