The evolutionarily conserved Wnt signaling pathway plays a central role in development and
adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling …

Dupuytren disease (DD) is a fibroproliferative disorder of unknown etiology that often results
in shortening and thickening of the palmar fascia, leading to permanent and irreversible …

Dupuytren's contracture (DC) is an inflammatory fibrosis characterized by fibroproliferative
disorders of the palmar aponeurosis, for which there is no effective treatment. Although …

Genetic background plays an important role in the development of Dupuytren's disease. A
genome-wide association study (GWAS) showed that nine loci are associated with the …

Dupuytren's disease is a fibroproliferative disease of the palmar fascia which has been
described for centuries, yet the aetiology and pathophysiology remain poorly understood …

Dupuytren's contracture, a proliferative disease of unknown origin, is characterized by an
abnormal fibroblast proliferation process. Evidence from numerous microRNA (miRNA) …

Arthrofibrosis (af) is defined as a fibrosing disease of the synovial membrane, after joint
operations, with painful restricted range of motion. The aim of this paper was to describe the …

The mechanism by which the fibroblast is able to trigger palmar fibromatosis is still not yet
fully understood. It would appear certain that the “abnormal” fibroblasts continuously …

Introduction Arthrofibrosis (AF) is the result of increased cell proliferation and synthesis of
matrix proteins (collagen I, III, and VI). Especially after invasive knee surgery, eg, ligament …

A role of Wnt signaling in Dupuytren disease, a fibroproliferative disease of the hand and
fingers, has not been fully elucidated. We examined a large set of Wnt pathway components …