Metabolomics in cancer research and emerging applications in clinical oncology
Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …
Indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy
Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the
oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune …
oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune …
Molecular mechanisms of treatment resistance in glioblastoma
A Ou, WKA Yung, N Majd - International journal of molecular sciences, 2020 - mdpi.com
Glioblastoma is the most common malignant primary brain tumor in adults and is almost
invariably fatal. Despite our growing understanding of the various mechanisms underlying …
invariably fatal. Despite our growing understanding of the various mechanisms underlying …
Immune microenvironment in glioblastoma subtypes
Z Chen, D Hambardzumyan - Frontiers in immunology, 2018 - frontiersin.org
Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to
their malignant growth and invasion into the brain parenchyma coupled with resistance to …
their malignant growth and invasion into the brain parenchyma coupled with resistance to …
IDO1 in cancer: a Gemini of immune checkpoints
L Zhai, E Ladomersky, A Lenzen, B Nguyen… - Cellular & molecular …, 2018 - nature.com
Abstract Indoleamine 2, 3-dioxygenase 1 (IDO1) is a rate-limiting metabolic enzyme that
converts the essential amino acid tryptophan (Trp) into downstream catabolites known as …
converts the essential amino acid tryptophan (Trp) into downstream catabolites known as …
Current immunotherapies for glioblastoma multiforme
B Huang, X Li, Y Li, J Zhang, Z Zong… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor found
in the central nervous system. Currently, standard treatments in the clinic include maximal …
in the central nervous system. Currently, standard treatments in the clinic include maximal …
The role of indoleamine-2, 3-dioxygenase in cancer development, diagnostics, and therapy
Tumors are composed of abnormally transformed cell types and tissues that differ from
normal tissues in their genetic and epigenetic makeup, metabolism, and immunology …
normal tissues in their genetic and epigenetic makeup, metabolism, and immunology …
Immunosuppressive IDO in cancer: mechanisms of action, animal models, and targeting strategies
Indoleamine 2, 3-dioxygenase 1 (IDO; IDO1; INDO) is a rate-limiting enzyme that
metabolizes the essential amino acid, tryptophan, into downstream kynurenines …
metabolizes the essential amino acid, tryptophan, into downstream kynurenines …
Tumor heterogeneity in glioblastomas: from light microscopy to molecular pathology
Simple Summary Glioblastomas (GBMs) are the most frequent and aggressive malignant
tumors arising in the human brain. One of the main reasons for GBM aggressiveness is its …
tumors arising in the human brain. One of the main reasons for GBM aggressiveness is its …
Mouse models of glioblastoma for the evaluation of novel therapeutic strategies
Glioblastoma (GBM) is an incurable brain tumor with a median survival of approximately 15
months despite an aggressive standard of care that includes surgery, chemotherapy, and …
months despite an aggressive standard of care that includes surgery, chemotherapy, and …