Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Oligodendrocytes are best known for wrapping myelin, a unique specialization that enables
energy-efficient and fast axonal impulse propagation in white matter tracts and fibers of the …

The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

The inability of the mammalian central nervous system (CNS) to undergo spontaneous
regeneration has long been regarded as a central tenet of neurobiology. However, while this …

Myelinating oligodendrocytes die in human disease and early in aging. Despite this, the
mechanisms that underly oligodendrocyte death are not resolved and it is also not clear …

Multiple sclerosis (MS), a prevalent neurological disorder, predominantly affects young
adults and is characterized by chronic autoimmune activity. The study explores the immune …

Myelination is essential for neuronal function and health. In peripheral nerves,> 100
causative mutations have been identified that cause Charcot-Marie-Tooth disease, a …

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

Myelin defects lead to neurological dysfunction in various diseases and in normal aging.
Chronic neuroinflammation often contributes to axon-myelin damage in these conditions …

Disruption of myelin, the fatty sheath-insulating nerve fibers in the white matter, blocks or
slows the rapid transmission of electrical signals along nerve cells and contributes to several …