Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Traditionally, arterial hypertension and subsequent end‐organ damage have been
attributed to haemodynamic factors, but increasing evidence indicates that inflammation also …

Air pollution is a major public health concern worldwide. Exposure to fine particulate matter
(PM2. 5) is closely associated with cardiovascular diseases. However, the effect of PM2. 5 …

Melatonin functions as an endogenous protective molecule in multiple vascular diseases,
whereas its effects on thoracic aortic aneurysm and dissection (TAAD) and underlying …

Background Mounting evidence suggests that complement components promote tumor
progression via modulating immune suppression, angiogenesis, or tumor cell proliferation …

Objective: Thoracic aortic dissection (TAD) is a fatal disease that leads to aortic rupture and
sudden death. However, little is known about the effect and molecular mechanism of S …

Sirtuin3 (Sirt3) is a histone deacetylase involved in the regulation of many cellular
processes. Sirt3 deficiency is known to increase oxidative stress. Reactive oxygen species …

The mechanistic basis for the formation of aortic aneurysms and dissection needs to be
elucidated to facilitate the development of effective medications. β-Aminopropionitrile …

Immune cell infiltration in response to myocyte death regulates extracellular matrix
remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain …

Thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute
onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not …