Interactions of small molecules with DNA junctions
The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …
[HTML][HTML] Junctions in DNA: underexplored targets for therapeutic intervention
E Ivens, MMD Cominetti, M Searcey - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
DNA has been a key target for cancer therapy, with a range of compounds able to bind and
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …
either impair its processing or induce damage. Targeting DNA with small molecules in a truly …
Ruthenium (II) polypyridyl complexes as FRET donors: structure-and sequence-selective DNA-binding and anticancer properties
Ruthenium (II) polypyridyl complexes (RPCs) that emit from metal-to-ligand charge transfer
(MLCT) states have been developed as DNA probes and are being examined as potential …
(MLCT) states have been developed as DNA probes and are being examined as potential …
[HTML][HTML] DNA folds threaten genetic stability and can be leveraged for chemotherapy
J Zell, FR Sperti, S Britton, D Monchaud - RSC Chemical Biology, 2021 - pubs.rsc.org
Damaging DNA is a current and efficient strategy to fight against cancer cell proliferation.
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …
Organometallic pillarplexes that bind DNA 4-way Holliday junctions and forks
JS Craig, L Melidis, HD Williams… - Journal of the …, 2023 - ACS Publications
Holliday 4-way junctions are key to important biological DNA processes (insertion,
recombination, and repair) and are dynamic structures that adopt either open or closed …
recombination, and repair) and are dynamic structures that adopt either open or closed …
Solution and Gas-Phase Stability of DNA Junctions from Temperature-Controlled Electrospray Ionization and Surface-Induced Dissociation
A Pruška, JA Harrison, A Granzhan… - Analytical …, 2023 - ACS Publications
DNA three-way junction (TWJ) structures transiently form during key cellular processes such
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …
as transcription, replication, and DNA repair. Despite their significance, the thermodynamics …
DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells
K Duskova, P Lejault, É Benchimol… - Journal of the …, 2019 - ACS Publications
Translocation of DNA and RNA polymerases along their duplex substrates results in DNA
supercoiling. This torsional stress promotes the formation of plectonemic structures …
supercoiling. This torsional stress promotes the formation of plectonemic structures …
Dangling Ligand Enables an Iron Hexa-Coordinated Molecular Catalyst for Water Oxidation by Photocatalysis
B Yang, Q Liu, XZ Wei, T Lei, QQ Yang… - CCS …, 2024 - chinesechemsoc.org
Photocatalytic water oxidation reaction by transition metal complexes remains a challenge
because of their poor stability under irradiation, especially for earth-abundant metal …
because of their poor stability under irradiation, especially for earth-abundant metal …
Identification of three-way DNA junction ligands through screening of chemical libraries and validation by complementary in vitro assays
K Duskova, J Lamarche, S Amor, C Caron… - Journal of medicinal …, 2019 - ACS Publications
The human genome is replete with repetitive DNA sequences that can fold into
thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular …
thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular …
Charge transport across DNA-based three-way junctions
DNA-based molecular electronics will require charges to be transported from one site within
a 2D or 3D architecture to another. While this has been shown previously in linear, π …
a 2D or 3D architecture to another. While this has been shown previously in linear, π …