Spatially and temporally controlled hydrogels for tissue engineering

J Leijten, J Seo, K Yue, G Trujillo-de Santiago… - Materials Science and …, 2017 - Elsevier
Recent years have seen tremendous advances in the field of hydrogel-based biomaterials.
One of the most prominent revolutions in this field has been the integration of elements or …

[HTML][HTML] Neural tissue engineering with structured hydrogels in CNS models and therapies

J George, CC Hsu, LTB Nguyen, H Ye, Z Cui - Biotechnology advances, 2020 - Elsevier
The development of techniques to create and use multiphase microstructured hydrogels
(granular hydrogels or microgels) has enabled the generation of cultures with more …

An injectable hybrid hydrogel with oriented short fibers induces unidirectional growth of functional nerve cells

A Omidinia‐Anarkoli, S Boesveld, U Tuvshindorj… - small, 2017 - Wiley Online Library
To regenerate soft aligned tissues in living organisms, low invasive biomaterials are
required to create 3D microenvironments with a structural complexity to mimic the tissue's …

Combinatorial therapies after spinal cord injury: how can biomaterials help?

T Führmann, PN Anandakumaran… - Advanced healthcare …, 2017 - Wiley Online Library
Traumatic spinal cord injury (SCI) results in an immediate loss of motor and sensory function
below the injury site and is associated with a poor prognosis. The inhibitory environment that …

Naturally occurring biological macromolecules-based hydrogels: Potential biomaterials for peripheral nerve regeneration

H Samadian, H Maleki, A Fathollahi, M Salehi… - International journal of …, 2020 - Elsevier
Despite the recent advances in the treatment strategies of peripheral nerve system defects,
peripheral nerve injury (PNI) is still one of the most important health issues with increasing …

Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination in vitro

S Wu, MS Chen, P Maurel, Y Lee… - Journal of neural …, 2018 - iopscience.iop.org
Objective. Polyvinylidene fluoride-trifluoroethylene (PVDF-TrFE), which is a piezoelectric,
biocompatible polymer, holds promise as a scaffold in combination with Schwann cells …

Development and in vitro differentiation of Schwann cells

SJ Hörner, N Couturier, DC Gueiber, M Hafner… - Cells, 2022 - mdpi.com
Schwann cells are glial cells of the peripheral nervous system. They exist in several
subtypes and perform a variety of functions in nerves. Their derivation and culture in vitro are …

Function Follows Form: Oriented Substrate Nanotopography Overrides Neurite-Repulsive Schwann Cell–Astrocyte Barrier Formation in an In Vitro Model of Glial …

P Achenbach, L Hillerbrand, JL Gerardo-Nava… - Nano Letters, 2023 - ACS Publications
Schwann cell (SC) transplantation represents a promising therapeutic approach for
traumatic spinal cord injury but is frustrated by barrier formation, preventing cell migration …

Bicyclic RGD peptides enhance nerve growth in synthetic PEG-based Anisogels

S Vedaraman, D Bernhagen, T Haraszti, C Licht… - Biomaterials …, 2021 - pubs.rsc.org
Nerve regeneration scaffolds often consist of soft hydrogels modified with extracellular
matrix (ECM) proteins or fragments, as well as linear and cyclic peptides. One of the …

Design of suspended melt electrowritten fiber arrays for schwann cell migration and neurite outgrowth

A Hrynevich, P Achenbach, T Jungst… - Macromolecular …, 2021 - Wiley Online Library
In this study, well‐defined, 3D arrays of air‐suspended melt electrowritten fibers are made
from medical grade poly (ɛ‐caprolactone)(PCL). Low processing temperatures, lower …