The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

Protein kinases play a predominant regulatory role in nearly every aspect of cell biology and
they can modify the function of a protein in almost every conceivable way. Protein …

The physiological Src proto-oncogene is a protein-tyrosine kinase that plays key roles in cell
growth, division, migration, and survival signaling pathways. From the N-to C-terminus, Src …

ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-
MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large …

The reversible phosphorylation of proteins ranks among the most important posttranslational
modifications that occur in the cell. In the last several decades, protein phosphorylation has …

A clinical casein kinase 2 inhibitor, CX-4945 (silmitasertib), shows significant affinity toward
the DYRK1A and GSK3β kinases, involved in down syndrome phenotypes, Alzheimer's …

FLUORESCENCEimaging is perhaps the most powerful technique currently available for
continuously observing the dynamic intracellular biochemistry of single living cells1 …

The epidermal growth factor receptor (EGFR) family consists of four members that belong to
the ErbB lineage of proteins (ErbB1–4). These receptors consist of an extracellular domain …

The ErbB/HER protein-tyrosine kinases, which include the epidermal growth factor receptor,
consist of a growth-factor-binding ectodomain, a single transmembrane segment, an …

Revised Manuscript Received December 17, 1992 abstract: The structure of a ternary
complex of the catalytic subunit of cAMP-dependent protein kinase, MgATP, and a 20 …