Shikonin and its derivatives, isolated from traditional medicinal plant species of the genus
Lithospermum, Alkanna, Arnebia, Anchusa, Onosma, and Echium belonging to the …

Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …

Gentamicin causes kidney injury due to its accumulation in proximal tubule epithelial cells
via the megalin/cubilin/CLC-5 complex. Recently, shikonin has been shown to have …

Parkinson's disease (PD) is a familiar neurodegenerative disease, accompanied by motor
retardation, static tremor, memory decline and dementia. Heredity, environment, age and …

Mycotoxin-induced liver injury is often accompanied by oxidative stress (OS) and
inflammation. This research aimed to explore the potential mechanism of sodium butyrate …

Pyruvate kinase is a key regulator in glycolysis through the conversion of
phosphoenolpyruvate (PEP) into pyruvate. Pyruvate kinase exists in various isoforms that …

E Se tea is a traditional herbal tea used in the prevention of liver diseases. However, the
hepatoprotective effect of E Se tea has not been investigated. This study aimed to determine …

Acetaminophen (APAP) overdose has long been considered a major cause of drug-induced
liver injury. Ferroptosis is a type of programmed cell death mediated by iron-dependent lipid …

Ethnopharmacological relevance ErZhiFormula (EZF) is a classical traditional Chinese
medicinal formulation. It can be used to treat liver and kidney yin deficiency, dizziness …

Emodin is a natural bioactive compound from traditional Chinese herbs that exerts anti-
inflammatory, antioxidant, anticancer, hepatoprotective, and neuroprotective effects …