Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness
and potential impact on cognition but also to its localized vertical integration of different …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Highlights•Diverse animal models of depression and anxiety have impaired neurogenesis.•
Neurogenesis is consistently boosted by antidepressants in animal models when animals …

The generation of new neurons is sustained throughout adulthood in the mammalian brain
due to the proliferation and differentiation of adult neural stem cells. In this review, we …

The neurogenesis hypothesis of depression was originally formed upon the demonstration
that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work …

Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety
disorders, and increasing evidence suggests potential use of these drugs beyond current …

Brain-derived neurotrophic factor (BDNF) signaling is integral to a range of neural functions,
including synaptic plasticity and exhibits activity-dependent regulation of expression. As …

The hippocampus is involved in both cognitive and emotional processing; these different
functions are topographically distributed along its septo-temporal axis, the dorsal (septal) …

Depression is a major contributor to the global burden of disease and disability, yet it is
poorly understood. Here we review data supporting a novel theoretical model for the biology …