The genomic landscape of pediatric acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL …
Hiplot: a comprehensive and easy-to-use web service for boosting publication-ready biomedical data visualization
Complex biomedical data generated during clinical, omics and mechanism-based
experiments have increasingly been exploited through cloud-and visualization-based data …
experiments have increasingly been exploited through cloud-and visualization-based data …
Immunotherapy for SMARCB1-deficient sarcomas: current evidence and future developments
C Ngo, S Postel-Vinay - Biomedicines, 2022 - mdpi.com
Mutations in subunits of the SWItch Sucrose Non-Fermentable (SWI/SNF) complex occur in
20% of all human tumors. Among these, the core subunit SMARCB1 is the most frequently …
20% of all human tumors. Among these, the core subunit SMARCB1 is the most frequently …
Genomes for kids: the scope of pathogenic mutations in pediatric cancer revealed by comprehensive DNA and RNA sequencing
S Newman, J Nakitandwe, CA Kesserwan, EM Azzato… - Cancer discovery, 2021 - AACR
Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-
risk disease. Here, we used a three-platform sequencing approach, including whole …
risk disease. Here, we used a three-platform sequencing approach, including whole …
A new genomic framework to categorize pediatric acute myeloid leukemia
Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …
driver alterations, many of which are underrepresented in the current classification schemas …
St. Jude Cloud: a pediatric cancer genomic data-sharing ecosystem
Effective data sharing is key to accelerating research to improve diagnostic precision,
treatment efficacy, and long-term survival in pediatric cancer and other childhood …
treatment efficacy, and long-term survival in pediatric cancer and other childhood …
Metabolomics in acute myeloid leukemia
AV Wojcicki, MM Kasowski, KM Sakamoto… - Molecular Genetics and …, 2020 - Elsevier
Acute myeloid leukemia (AML) is a complex, heterogenous hematological malignancy
caused by mutations in myeloid differentiation and proliferation. Response to therapy and …
caused by mutations in myeloid differentiation and proliferation. Response to therapy and …
Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia
The genetics of relapsed pediatric acute myeloid leukemia (AML) has yet to be
comprehensively defined. Here, we present the spectrum of genomic alterations in 136 …
comprehensively defined. Here, we present the spectrum of genomic alterations in 136 …
NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition
Disruption of antagonism between SWI/SNF chromatin remodelers and polycomb repressor
complexes drives the formation of numerous cancer types. Recently, an inhibitor of the …
complexes drives the formation of numerous cancer types. Recently, an inhibitor of the …
Distinct genomic landscape of Chinese pediatric acute myeloid leukemia impacts clinical risk classification
T Liu, J Rao, W Hu, B Cui, J Cai, Y Liu, H Sun… - Nature …, 2022 - nature.com
Studies have revealed key genomic aberrations in pediatric acute myeloid leukemia (AML)
based on Western populations. It is unknown to what extent the current genomic findings …
based on Western populations. It is unknown to what extent the current genomic findings …