Mechanisms of metabolic reprogramming in cancer cells supporting enhanced growth and proliferation

C Schiliro, BL Firestein - Cells, 2021 - mdpi.com
Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

[HTML][HTML] Mechanoresponsive metabolism in cancer cell migration and metastasis

MR Zanotelli, J Zhang, CA Reinhart-King - Cell metabolism, 2021 - cell.com
Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Targeting glucose metabolism to suppress cancer progression: prospective of anti-glycolytic cancer therapy

AF Abdel-Wahab, W Mahmoud, RM Al-Harizy - Pharmacological research, 2019 - Elsevier
Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely
on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which …

Signal pathways and precision therapy of small-cell lung cancer

M Yuan, Y Zhao, HT Arkenau, T Lao, L Chu… - Signal transduction and …, 2022 - nature.com
Small-cell lung cancer (SCLC) encounters up 15% of all lung cancers, and is characterized
by a high rate of proliferation, a tendency for early metastasis and generally poor prognosis …

Targeting metabolism in cancer cells and the tumour microenvironment for cancer therapy

J Li, JQ Eu, LR Kong, L Wang, YC Lim, BC Goh… - Molecules, 2020 - mdpi.com
Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer
treatment. The metabolic reprogramming that accompanies the development of malignancy …

Inhibition of glycolysis and glutaminolysis: an emerging drug discovery approach to combat cancer

NS Akins, TC Nielson, HV Le - Current topics in medicinal …, 2018 - ingentaconnect.com
Cancer cells have a very different metabolism from that of normal cells from which they are
derived. Their metabolism is elevated, which allows them to sustain higher proliferative rate …

Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies

Y Zhang, Q Li, Z Huang, B Li, EC Nice, C Huang, L Wei… - Cancers, 2022 - mdpi.com
Simple Summary Reprogramming of glucose metabolism is a hallmark of cancer and can be
targeted by therapeutic agents. Some metabolism regulators, such as ivosidenib and …

Metabolic reprogramming in cancer: Mechanisms and therapeutics

S Nong, X Han, Y Xiang, Y Qian, Y Wei, T Zhang… - MedComm, 2023 - Wiley Online Library
Cancer cells characterized by uncontrolled growth and proliferation require altered
metabolic processes to maintain this characteristic. Metabolic reprogramming is a process …

“An apple a day keeps the doctor away”: The potentials of apple bioactive constituents for chronic disease prevention

AB Oyenihi, ZA Belay, A Mditshwa… - Journal of food …, 2022 - Wiley Online Library
Apples are rich sources of selected micronutrients (eg, iron, zinc, vitamins C and E) and
polyphenols (eg, procyanidins, phloridzin, 5′‐caffeoylquinic acid) that can help in …

Targeting glucose transporters for breast cancer therapy: the effect of natural and synthetic compounds

AM Barbosa, F Martel - Cancers, 2020 - mdpi.com
Reprogramming of cellular energy metabolism is widely accepted to be a cancer hallmark.
The deviant energetic metabolism of cancer cells-known as the Warburg effect-consists in …