Roles of Porphyromonas gingivalis and its virulence factors in periodontitis

W Xu, W Zhou, H Wang, S Liang - Advances in protein chemistry and …, 2020 - Elsevier
Periodontitis is an infection-driven inflammatory disease, which is characterized by gingival
inflammation and bone loss. Periodontitis is associated with various systemic diseases …

Novel mechanisms and functions of complement

G Hajishengallis, ES Reis, DC Mastellos, D Ricklin… - Nature …, 2017 - nature.com
Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

KY How, KP Song, KG Chan - Frontiers in microbiology, 2016 - frontiersin.org
Periodontal disease represents a group of oral inflammatory infections initiated by oral
pathogens which exist as a complex biofilms on the tooth surface and cause destruction to …

Molecular aspects of the pathogenesis of periodontitis

J Meyle, I Chapple - Periodontology 2000, 2015 - Wiley Online Library
The past decade of basic research in periodontology has driven radical changes in our
understanding and perceptions of the pathogenic processes that drive periodontal tissue …

Complement in cancer: untangling an intricate relationship

ES Reis, DC Mastellos, D Ricklin… - Nature Reviews …, 2018 - nature.com
In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Pathogenesis of Important Virulence Factors of Porphyromonas gingivalis via Toll-Like Receptors

L Jia, N Han, J Du, L Guo, Z Luo, Y Liu - Frontiers in cellular and …, 2019 - frontiersin.org
Periodontitis is a common intraoral infection and is inextricably linked to systemic diseases.
Recently, the regulation between host immunologic response and periodontal pathogens …

Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome

X Wang, Y Jia, L Wen, W Mu, X Wu, T Liu, X Liu, J Fang… - Cancer Research, 2021 - AACR
Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with
various digestive cancers. However, whether P. gingivalis can promote colorectal cancer …

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

G Hajishengallis - Trends in immunology, 2014 - cell.com
Recent studies have uncovered novel mechanisms underlying the breakdown of periodontal
host–microbe homeostasis, which can precipitate dysbiosis and periodontitis in susceptible …

New developments in neutrophil biology and periodontitis

G Hajishengallis - Periodontology 2000, 2020 - Wiley Online Library
Neutrophils have been historically associated with antimicrobial functions in acute infections
but are now appreciated as functionally versatile cells with critical roles in chronic …

Porphyromonas gingivalis Periodontal Infection and Its Putative Links with Alzheimer's Disease

SK Singhrao, A Harding, S Poole… - Mediators of …, 2015 - Wiley Online Library
Periodontal disease (PD) and Alzheimer's disease (AD) are inflammatory conditions
affecting the global adult population. In the pathogenesis of PD, subgingival complex …