Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell
dysfunction, and ultimately type 2 diabetes (T2D). This chronic inflammatory state …

The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Obesity is a state of low-grade chronic inflammation that causes multiple metabolic
diseases. During obesity, signalling via cytokines of the TNF family mediate cell death and …

Several lines of preclinical and clinical research have confirmed that chronic low-grade
inflammation of adipose tissue is mechanistically linked to metabolic disease and organ …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

In response to a wide range of stimulations, host cells activate pyroptosis, a kind of
inflammatory cell death which is provoked by the cytosolic sensing of danger signals and …

Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb
Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains …