Migration of leukocytes is essential for the induction, maintenance, and regulation of
immune responses. On their trafficking routes, leukocytes encounter microenvironments of …

INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …

Exogenous mechanical cues are transmitted from the extracellular matrix to the nuclear
envelope (NE), where mechanical stress on the NE mediates shuttling of transcription …

Amoeboid cell types are fundamental to animal biology and broadly distributed across
animal diversity, but their evolutionary origin is unclear. The closest living relatives of …

ABSTRACT The EMBO/EMBL Symposium 'Mechanical Forces in Development'was held in
Heidelberg, Germany, on 3-6 July 2019. This interdisciplinary symposium brought together …

Through the process of regulating cell deformability in confined environments, the nucleus
has emerged as a major regulator of cell migration. Here, we demonstrate that nuclear …

In this project we have characterised the dynamics of single myosin II molecules in stem
cells under mechanical stress combining high spatial and time resolution microscopy with …

Upon infection, mature dendritic cells (mDCs) migrate from peripheral tissue to lymph nodes
and initiate the adaptive immune response. This fast and tightly regulated process imposes …