G-quadruplex is a special secondary structure of nucleic acids in guanine-rich sequences of
genome. G-quadruplexes have been proved to be involved in the regulation of replication …

Long non-coding RNAs (lncRNAs) are an emerging class of transcripts that can modulate
gene expression; however, their mechanisms of action remain poorly understood. Here, we …

Background Cellular nucleic acid binding protein (CNBP) is a conserved single-stranded
nucleic acid binding protein present in most eukaryotes, but not in plants. Expansions in the …

MYC is overexpressed in many different cancer types and is an intensively studied
oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex …

Glycogen metabolism commonly altered in cancer is just beginning to be understood.
Phosphoglucomutase 1 (PGM1), the first enzyme in glycogenesis that catalyzes the …

Guanine-rich DNA strands can fold into non-canonical four-stranded secondary structures
named G-quadruplexes (G4). Experimental evidences suggest that G4-DNA surrounding …

Guanine-rich and cytosine-rich DNA can form four-stranded DNA secondary structures
called G-quadruplex (G4) and i-motif, respectively. These structures widely exist in genomes …

Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of
tumor stroma-expressed Hx in suppressing cancer progression. Labile heme and Hx levels …

Targeted drug delivery system in the form of herbal based nano-formulations is the new ray
of hope for minimizing the side effects related to the anti-cancer drugs as well as …

Background Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid
gland tumor and lacks effective therapy. N6-Methyladenosine (m 6 A) is the most prevalent …